European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Division of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA.
Genetics. 2022 Apr 4;220(4). doi: 10.1093/genetics/iyac003.
WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.
WormBase（www.wormbase.org）是线虫秀丽隐杆线虫遗传学和基因组学的中央存储库。我们为研究界提供数据和工具，以促进秀丽隐杆线虫和相关线虫作为研究人类健康、发育和许多基础生物学方面的模型生物的应用。在我们 22 年的历史中，我们不断发展，以反映参与秀丽隐杆线虫研究的科学和技术的进步和创新。我们努力纳入新的数据类型和更丰富的数据集，并提供集成的显示和服务，利用已发表的线虫遗传学文献所产生的知识。在这里，我们从数据类型、策展工作流程、分析和工具等方面广泛概述了当前的 WormBase 状态，包括单细胞数据分析、文本挖掘和可视化以及新的社区协作论坛的令人兴奋的新进展。同时，我们继续与基因组资源联盟（WormBase 是其创始成员之一）整合和协调基础设施、流程和工具。
