Doctoral Program on Public Health, Universitas Sebelas Maret, Surakarta, Indonesia.
Department of Public Health, Universitas Veteran Bangun Nusantara, Sukoharjo, Indonesia.
J Prev Med Public Health. 2022 Jan;55(1):37-48. doi: 10.3961/jpmph.21.490. Epub 2022 Jan 10.
Depression is a frequent complication of type 2 diabetes mellitus. This study aimed to investigate the relationship between low social support and risk for depression in people with type 2 diabetes through a meta-analysis.
PubMed, ProQuest, SpringerLink, ScienceDirect, Scopus, the Cochrane Library, Embase, and Google Scholar were searched for English-language articles published up to 2021. Pooled adjusted odds ratios (aORs) were calculated using a random-effect model with 95% confidence intervals (CIs). Heterogeneity was evaluated by using the Cochrane Q test and I2 statistics. The risk of publication bias was estimated using a funnel plot, the Egger test, and the Begg test. The Joanna Briggs Institute Critical Appraisal Tools were used to assess the quality of evidence and the risk of bias.
Eleven studies were included in this meta-analysis, containing a total of 3151 people with type 2 diabetes mellitus. The pooled analysis showed that people with type 2 diabetes mellitus who had low social support had twice as high a risk of depression as those with high social support (aOR, 2.02; 95% CI, 1.51 to 2.70; p<0.001). A random-effect model was used because the heterogeneity was high (I2= 87%).
Low social support was found to increase the risk of depression among people with type 2 diabetes mellitus. Further investigation into factors that may moderate this relationship is required.
抑郁症是 2 型糖尿病的常见并发症。本研究旨在通过荟萃分析探讨 2 型糖尿病患者低社会支持与抑郁风险之间的关系。
检索了截至 2021 年发表的英文文献，包括 PubMed、ProQuest、SpringerLink、ScienceDirect、Scopus、Cochrane Library、Embase 和 Google Scholar。使用随机效应模型计算合并调整后的优势比（aOR）及其 95%置信区间（CI）。采用 Cochrane Q 检验和 I2 统计量评估异质性。使用漏斗图、Egger 检验和 Begg 检验评估发表偏倚的风险。采用 Joanna Briggs 研究所循证医学中心的批判性评估工具评估证据质量和偏倚风险。
本荟萃分析纳入了 11 项研究，共包含 3151 名 2 型糖尿病患者。汇总分析显示，低社会支持的 2 型糖尿病患者患抑郁症的风险是高社会支持患者的两倍（aOR，2.02；95%CI，1.51 至 2.70；p<0.001）。由于异质性较高（I2=87%），采用了随机效应模型。
低社会支持与 2 型糖尿病患者的抑郁风险增加有关。需要进一步研究可能调节这种关系的因素。
