Department of Public Health, College of Health Science, Debre Markos University, Debre Markos, Amhara, Ethiopia
Department of Nutrition, College of Health Science, Debre Markos University, Debre Markos, Amhara, Ethiopia.
BMJ Open. 2022 May 11;12(5):e061801. doi: 10.1136/bmjopen-2022-061801.
The adverse effects of poor social support on quality of life and adherence to treatment are established. However, the relationship between social support and depression is not well understood. In this systematic review and meta-analysis, we aim to examine the association between social support and depressive symptoms among type 2 patients with diabetes.
Systematic review and meta-analysis.
We searched PubMed, African Journals Online, Web of Science, and the Cochrane Library electronic databases. Some studies were also identified through manual Google search and Google scholar.
We systematically searched electronic databases for studies published up to October 2020. Only English-language articles were included.
Screening, data extraction and quality appraisal were conducted by two independent reviewers. A random-effect model was applied to estimate ORs with 95% CIs. The Higgins I test was used to assess the heterogeneity between the studies. The risk of publication bias was estimated using the Egger test. Leave-one-out analysis was done. Data were analysed using Stata V.11.
Seven studies were included in the meta-analysis. The findings from included studies revealed that poor social support increases the odds of depression among patients with diabetes (adjusted OR=2.14, 95% CI 1.34 to 3.43, p=0.003). There was no risk of publication bias (p=0.064), and heterogeneity was substantial (I=70.7%). The leave-one-out analysis confirmed the consistency of the findings.
Our meta-analysis revealed that patients who had poor social support were significantly associated with an increased level of depression. Additional studies exploring factors that might moderate or mediate this association are needed. Targeted interventions for comorbid depression should be implemented in clinical practice.
We have submitted the protocol for registration at the PROSPERO on 9 October 2020. But we have not yet received a registration number.
不良的社会支持对生活质量和治疗依从性的不良影响已得到证实。然而，社会支持与抑郁之间的关系尚不清楚。在本系统评价和荟萃分析中，我们旨在研究 2 型糖尿病患者的社会支持与抑郁症状之间的关系。
系统评价和荟萃分析。
我们检索了 PubMed、African Journals Online、Web of Science 和 Cochrane Library 电子数据库。还通过手动 Google 搜索和 Google Scholar 识别了一些研究。
我们系统地检索了截至 2020 年 10 月发表的电子数据库中的研究。仅纳入英文文章。
两位独立评审员进行了筛选、数据提取和质量评估。应用随机效应模型估计 OR 值及其 95%置信区间。Higgins I 检验用于评估研究间的异质性。Egger 检验用于估计发表偏倚的风险。采用剔除一个研究的方法进行分析。使用 Stata V.11 进行数据分析。
荟萃分析纳入了 7 项研究。纳入研究的结果表明，社会支持不良会增加糖尿病患者患抑郁症的几率（调整后的 OR=2.14，95%CI 1.34 至 3.43，p=0.003）。不存在发表偏倚的风险（p=0.064），且存在较大的异质性（I=70.7%）。剔除一个研究的分析证实了研究结果的一致性。
我们的荟萃分析显示，社会支持不良的患者与抑郁水平升高显著相关。需要开展更多研究来探索可能调节或介导这种关联的因素。应在临床实践中实施针对共病性抑郁的靶向干预措施。
我们已于 2020 年 10 月 9 日向 PROSPERO 提交了注册方案，但尚未收到注册号。
