Yamauchi K, Furui H, Taniguchi N, Sotobata I
Am J Cardiol. 1986 Mar 1;57(8):609-12. doi: 10.1016/0002-9149(86)90844-1.
The effects of diltiazem hydrochloride on exercise-induced changes in cardiovascular response, plasma renin activity, platelet function and blood coagulability were evaluated with multistage treadmill exercise in 20 patients who had systemic hypertension of stage 1 to 2 (World Health Organization classification). Heart rates, blood pressure, and pressure-rate product at rest, at peak exercise and in the recovery period were significantly reduced after 4 weeks of diltiazem administration, 180 mg/day. Plasma renin activity tended to increase after the medication. However, platelet adenosine diphosphate-induced aggregation sensitivity, prothrombin time, activated partial thromboplastin time, plasma fibrinogen concentration and antithrombin III activity did not change significantly. It is concluded that diltiazem could ameliorate the hyperresponsiveness of heart rate and BP to exercise in hypertensive patients without affecting blood coagulability.
在20例1至2期系统性高血压患者（世界卫生组织分类）中，采用多级跑步机运动评估盐酸地尔硫䓬对运动诱导的心血管反应、血浆肾素活性、血小板功能和血液凝固性变化的影响。给予地尔硫䓬180毫克/天，4周后，静息、运动峰值和恢复期的心率、血压及压力-心率乘积均显著降低。用药后血浆肾素活性有升高趋势。然而，血小板二磷酸腺苷诱导的聚集敏感性、凝血酶原时间、活化部分凝血活酶时间、血浆纤维蛋白原浓度和抗凝血酶III活性无显著变化。结论是，地尔硫䓬可改善高血压患者心率和血压对运动的高反应性，而不影响血液凝固性。
