Hoogwerf B J, Laine D C, Greene E
Am J Clin Nutr. 1986 Mar;43(3):350-60. doi: 10.1093/ajcn/43.3.350.
We studied effects of isocaloric diets of varied composition (each diet offered for 5 to 7 days) on urine C-peptide and creatinine excretion in eight healthy subjects. C-peptide excretion was higher on the high carbohydrate (60% CHO, 20% PRO) and high protein (45% CHO, 30% PRO) diets than on the low carbohydrate (30% CHO, 20% PRO) and low protein diets (45% CHO, 10% PRO). C-peptide excretion correlated with total kilocalories ingested (r = 0.594, p less than 0.001), and also with CHO (r = 0.469, p = 0.003) and PRO intake (r = 0.453, p = 0.004). Multiple regression analysis is given by the formula: Urine C-peptide (nmol/24 h) = 17.3 + 0.01 (kcal/24 h) + 0.021 (gm CHO/24 h) + 0.049 (gm PRO/24 h) Creatinine excretion was related to body weight (r = 0.959, p less than 0.001) and also to total PRO intake (r = 0.569, p less than 0.001) and meat intake (r = 0.367, p less than 0.05). We conclude that diet composition, especially protein intake, is an important stimulus to sustained insulin production as measured by C-peptide in healthy subjects. Diet composition has a significant impact on creatinine excretion. Urine creatinine cannot be assumed to reflect only lean body weight when it is used as a measure of the adequacy of timed urine collections.
我们研究了不同成分的等热量饮食（每种饮食提供5至7天）对8名健康受试者尿C肽和肌酐排泄的影响。高碳水化合物（60%碳水化合物，20%蛋白质）和高蛋白（45%碳水化合物，30%蛋白质）饮食组的C肽排泄量高于低碳水化合物（30%碳水化合物，20%蛋白质）和低蛋白饮食组（45%碳水化合物，10%蛋白质）。C肽排泄与摄入的总千卡数相关（r = 0.594，p < 0.001），也与碳水化合物（r = 0.469，p = 0.003）和蛋白质摄入量（r = 0.453，p = 0.004）相关。多元回归分析由以下公式给出：尿C肽（nmol/24小时）= 17.3 + 0.01（千卡/24小时）+ 0.021（克碳水化合物/24小时）+ 0.049（克蛋白质/24小时）。肌酐排泄与体重相关（r = 0.959，p < 0.001），也与总蛋白质摄入量（r = 0.569，p < 0.001）和肉类摄入量（r = 0.367，p < 0.05）相关。我们得出结论，饮食成分，尤其是蛋白质摄入量，是健康受试者中通过C肽测量的持续胰岛素产生的重要刺激因素。饮食成分对肌酐排泄有显著影响。当尿肌酐用作定时尿液收集充足性的衡量指标时，不能认为它仅反映瘦体重。
