Butler J P, Spratt D I, O'Dea L S, Crowley W F
Am J Physiol. 1986 Mar;250(3 Pt 1):E338-40. doi: 10.1152/ajpendo.1986.250.3.E338.
Luteinizing hormone (LH) is released from the anterior pituitary gland in an episodic pattern driven by pulses of gonadotropin-releasing hormone (GnRH) from the hypothalamus. Autocorrelation analysis of the sequence of interpulse intervals of LH secretion in normal men supports the hypothesis that the underlying mechanism driving LH secretion is a renewal process. That is, whatever "memory" the GnRH pulse generator (i.e., the hypothalamus or its antecedent neural drive) may have, it does not go back in time further than the preceding secretory pulse. Thus the hypothalamic timer starts over again each time there is a GnRH secretory episode.
促黄体生成素（LH）由垂体前叶以脉冲式释放，其脉冲由下丘脑促性腺激素释放激素（GnRH）的脉冲驱动。对正常男性LH分泌脉冲间期序列进行自相关分析，支持了驱动LH分泌的潜在机制是一个更新过程的假说。也就是说，无论GnRH脉冲发生器（即下丘脑或其先前的神经驱动）可能具有何种“记忆”，它都不会追溯到比前一个分泌脉冲更远的时间。因此，每次GnRH分泌发作时，下丘脑计时器都会重新开始。
