Veldhuis Johannes D, Keenan Daniel M, Pincus Steven M
Endocrine Research Unit, Department of Internal Medicine, Mayo Medical School, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota 55905, USA.
Endocr Rev. 2008 Dec;29(7):823-64. doi: 10.1210/er.2008-0005. Epub 2008 Oct 21.
Endocrine glands communicate with remote target cells via a mixture of continuous and intermittent signal exchange. Continuous signaling allows slowly varying control, whereas intermittency permits large rapid adjustments. The control systems that mediate such homeostatic corrections operate in a species-, gender-, age-, and context-selective fashion. Significant progress has been made in understanding mechanisms of adaptive interglandular signaling in vivo. Principal goals are to understand the physiological origins, significance, and mechanisms of pulsatile hormone secretion. Key analytical issues are: 1) to quantify the number, size, shape, and uniformity of pulses, nonpulsatile (basal) secretion, and elimination kinetics; 2) to evaluate regulation of the axis as a whole; and 3) to reconstruct dose-response interactions without disrupting hormone connections. This review will focus on the motivations driving and the methodologies used for such analyses.
内分泌腺通过连续和间歇性信号交换的混合方式与远处的靶细胞进行通信。连续信号传导允许进行缓慢变化的控制，而间歇性则允许进行大幅度快速调整。介导这种稳态校正的控制系统以物种、性别、年龄和情境选择性的方式运作。在理解体内适应性腺间信号传导机制方面已经取得了重大进展。主要目标是了解脉冲式激素分泌的生理起源、意义和机制。关键的分析问题包括：1）量化脉冲的数量、大小、形状和均匀性、非脉冲式（基础）分泌以及消除动力学；2）评估整个轴的调节；3）在不破坏激素连接的情况下重建剂量反应相互作用。本综述将重点关注驱动此类分析的动机和所使用的方法。
