Department of Ophthalmology, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Dalseo-gu, Daegu, 42601, Republic of Korea.
Sci Rep. 2022 Feb 8;12(1):2051. doi: 10.1038/s41598-022-06121-x.
This retrospective study evaluated changes in the central retinal thickness (CRT) and the risk factors for neovascular glaucoma (NVG) after intravitreal bevacizumab injection under a pro re nata (PRN) regimen for macular oedema in 57 eyes with central retinal vein occlusion (CRVO). The clinical characteristics at the time of NVG diagnosis were assessed, and baseline and final clinical characteristics and mean CRT values at 1-, 3-, and 6-month follow-up evaluations were recorded. The incidence of NVG was 21.1%, with the neovascular group (12 eyes) showing poor baseline and final visual acuity, a higher incidence of baseline ischaemic-type CRVO and subretinal fluid, a higher mean CRT at the 1-month follow-up, and a higher number of intravitreal bevacizumab injections during the 6-month follow-up. Nine eyes with NVG (75%) showed a mean CRT < 300 μm at the time of diagnosis. An ischaemic CRVO and higher CRT at the 1-month follow-up were related to the development of NVG in the multivariate analysis. Thus, NVG development in CRVO patients treated with intravitreal bevacizumab injections was associated with an ischaemic CRVO and elevated CRT at the 1-month follow-up; PRN bevacizumab regimens based on CRT or control of macular oedema did not completely prevent NVG development.
这项回顾性研究评估了 57 只中央视网膜静脉阻塞（CRVO）患眼中，在接受玻璃体腔内贝伐单抗 PRN 治疗黄斑水肿后，中央视网膜厚度（CRT）的变化，以及新生血管性青光眼（NVG）的危险因素。评估了 NVG 诊断时的临床特征，并记录了基线和最终临床特征以及 1、3 和 6 个月随访时的平均 CRT 值。NVG 的发生率为 21.1%，新生血管组（12 只眼）的基线和最终视力较差，基线缺血型 CRVO 和视网膜下液的发生率较高，1 个月随访时平均 CRT 较高，且在 6 个月的随访期间接受了更多次的玻璃体腔内贝伐单抗注射。9 只 NVG 眼（75%）在诊断时的平均 CRT<300μm。多变量分析显示，缺血性 CRVO 和 1 个月随访时较高的 CRT 与 NVG 的发生有关。基于 CRT 或黄斑水肿控制的 PRN 贝伐单抗方案并不能完全预防 NVG 的发生。
