A study of dengue encephalitis with laboratory and clinical parameters in Tertiary Center of North India.

INTRODUCTION

With expanding clinical spectrum of dengue fever, encephalitis has been documented with increasing frequency. The aim of this study was to investigate the incidence, predictors and prognostic factors of dengue encephalitis (DE) in the setting of dengue viruses (DENV) infection.

MATERIALS AND METHODS

A hospital-based prospective cohort study was carried out, which included laboratory confirmed dengue positive cases. All dengue cases were categorized into nonencephalitis or encephalitis group. We estimated DE incidence and analyzed clinical, laboratory and neuroimaging data on admission, discharge and follow-up for 3 months to assess its predictors and prognostic factors.

RESULTS

Out of the enrolled 540 confirmed dengue cases, 27 patients had DE, representing 5% incidence. Two third of the DE patients were 20 years of age or younger, with male preponderance (81.5%). Fever, headache, and altered sensorium were present in >90% on admission. Significant predictors of encephalitis were mean body temperature during fever ( < 0.001), headache ( = 0.015), secondary dengue ( = 0.005), dengue hemorrhagic fever ( < 0.001), elevated hematocrit ( < 0.001), liver function test derangement ( < 0.05), and low platelet count ( = 0.006). Poor outcome factors for DE patients were prolonged duration of fever ( < 0.001), seizure ( = 0.002), and cerebrospinal fluid (CSF) DENV positivity ( = 0.049). One third patients died and the remainder of them recovered. An increasingly higher incidence rate with high mortality of DE is reported.

CONCLUSION

Clinical and laboratory parameter along with DENV positivity in CSF can predict and prognosticate dengue encephalitis.