Nickoloff B J, Fleischmann H E, Carmel J, Wood C C, Roth R J
Arch Dermatol. 1986 Mar;122(3):290-4. doi: 10.1001/archderm.122.3.290.
Microcystic adnexal carcinoma (MAC) is a locally aggressive neoplasm that has recently been recognized as a clinicopathologic entity. Its histologic appearance includes both pilar and eccrine differentiation. We initially treated two patients with MAC of the cheek and of the nasolabial fold, respectively; by microscopically controlled excision because of the contiguous growth of the tumors. Despite the benign histologic appearance, there was deep and extensive infiltration of the subcutaneous tissue. Both patients responded favorably to initial treatment with microscopically controlled excision. In addition, immunoperoxidase staining for carcinoembryonic antigen supported the dual differentiation of this unusual neoplasm. We speculate that previous radiotherapy may be an important predisposing factor in the pathogenesis of MAC.
微囊性附属器癌（MAC）是一种具有局部侵袭性的肿瘤，最近被确认为一种临床病理实体。其组织学表现包括毛囊和汗腺分化。我们最初分别治疗了两名脸颊和鼻唇沟患有MAC的患者；由于肿瘤呈浸润性生长，采用显微镜控制下的切除术。尽管组织学表现为良性，但皮下组织有深部和广泛的浸润。两名患者对显微镜控制下的初始切除术反应良好。此外，癌胚抗原的免疫过氧化物酶染色支持了这种不寻常肿瘤的双重分化。我们推测，既往放疗可能是MAC发病机制中的一个重要诱发因素。
