Department of Life Sciences, University of Siena, Siena, Italy.
Department of Health Sciences, Biostatistics Unit, University of Genoa, Genoa, Italy.
Adv Exp Med Biol. 2021;1353:91-113. doi: 10.1007/978-3-030-85113-2_6.
Unexpectedly, Italy was the first Western country to face COVID-19 outbreak, but promptly it was the first one to adopt stringent procedures to stem the spread of infection. The objective of this study was to describe the epidemiological situation and comorbidities in Italy, in addition to containment measures and health system and social protection strengthening ones applied in this country.
Available population data were collected, managed, and analysed from the daily reports on COVID-19 published every day, from 1 February to 8 June 2020.
Lombardia, a northern region of Italy, is considered the epicentre for the wave of the infection with the first diagnosed case, but in a few weeks other regions were involved (with Piemonte, Emilia-Romagna, and Veneto covering more than 70% of the Italian total cases). In the European context, after 3 months of containing measures of the sanitary emergency, Italy is the fourth country for the number of total positive cases (with 235,278 total case as at 8 June 2020), after Russia, the United Kingdom, and Spain, whereas it is the second for the number of deaths (with 33,964 deaths as at 8 June 2020), only after the United Kingdom. Regarding incidence, the curve of daily new cases shows an increasing trend up to 22 March 2020 with 6557 new daily cases and then a decreasing trend up to 280 as at 8 June. This turnaround can be explained by the application of national lockdown starting from 9 March and by the following 14 days of incubation of infection. Profiles of subjects at major risk of poor prognosis and death for COVID-19 are elderly (mean age of 80 years) and with three or more comorbidities. These characteristics can partially explain the high lethality rate for coronavirus observed in Italy, which is the European country with the highest share of elderly. In addition, other possible explanations of this high lethality are differences in testing policies among countries that influence the number of asymptomatic or pauci-symptomatic patients diagnosed as coronavirus positive, together with differences in definition and in the way of recording deaths for coronavirus. In the absence of a vaccine, severe nonpharmaceutical interventions (NPIs), including national lockdown, quarantine, social distancing, and use of facial masks, have been applied with success to reduce the virus spread and the burden on the National Health System. In addition to these stringent containment measures to fight the pandemic, other policies have been adopted searching to ensure economic sustainability, social safety, and stability.
Italy was the first Western country with a wide spread of COVID-19, but it was the first one to introduce containment restrictions, tightening them week by week and subjecting the 60 million people living in the country to unprecedented limitations. Many measurements have been adopted by the government, such as lockdown during the early stages of infection and subsequent social distancing and wearing face masks in public areas. Italians were compliant with all the measures ordered by the government and their discipline reflected in the COVID numbers: the curve of daily new cases after a peak at the end of March now shows a consistent decreasing trend up. In this phase of current reduction of virus diffusion, it is crucial to accommodate the need to continue protecting citizens from the risk of infection with the undeferrable, although gradual, restart of the economic and social system. This new scenario requires an active collaboration among all the actors: statutory bodies, employers, civil society, and the third sector.
出人意料的是,意大利是第一个面临新冠疫情的西方国家,但它也是第一个采取严格措施来遏制疫情传播的国家。本研究的目的是描述意大利的流行病学情况和合并症,以及在该国实施的遏制措施、卫生系统和社会保护措施的加强。
从 2020 年 2 月 1 日至 6 月 8 日每天发布的新冠疫情日报中收集、管理和分析可用的人口数据。
意大利北部的伦巴第大区被认为是疫情传播的中心,首例确诊病例就出现在这里,但在几周内,其他地区也相继出现了病例(皮埃蒙特、艾米利亚-罗马涅和威尼托地区占意大利总病例的 70%以上)。在欧洲范围内,经过 3 个月的卫生紧急情况遏制措施后,意大利的新冠确诊病例总数位居第四(截至 2020 年 6 月 8 日,共有 235278 例确诊病例),仅次于俄罗斯、英国和西班牙,而死亡人数位居第二(截至 2020 年 6 月 8 日,有 33964 人死亡),仅次于英国。就发病率而言,每日新增病例曲线在 2020 年 3 月 22 日达到 6557 例的峰值,随后呈下降趋势,截至 6 月 8 日降至 280 例。这种趋势的转变可以用从 3 月 9 日开始的全国封锁以及随后 14 天的感染潜伏期来解释。在新冠病毒方面预后不良和死亡风险较高的人群特征是老年人(平均年龄 80 岁)和有三种或更多合并症。这些特征可以部分解释意大利观察到的高死亡率,因为意大利是欧洲老年人口比例最高的国家。此外,各国在检测政策方面的差异影响了无症状或轻症患者被诊断为新冠病毒阳性的数量,这也可能是导致死亡率高的其他原因,此外,对冠状病毒死亡的定义和记录方式也存在差异。在没有疫苗的情况下,包括全国封锁、隔离、社交距离和使用口罩在内的严重非药物干预措施已成功实施,以减少病毒传播和国家卫生系统的负担。除了这些遏制大流行的严格措施外,还采取了其他政策来确保经济可持续性、社会安全和稳定。
意大利是第一个新冠病毒广泛传播的西方国家,但它也是第一个引入遏制措施的国家,这些措施每周都在收紧,并使居住在该国的 6000 万人面临前所未有的限制。政府采取了许多措施,例如在感染早期实施封锁,随后在公共场所实行社交距离和佩戴口罩。意大利人遵守政府发布的所有措施,他们的纪律体现在新冠病毒数据中:3 月底达到峰值后,每日新增病例曲线现在呈持续下降趋势。在当前病毒扩散减少的阶段,至关重要的是,要在不推迟但要逐步恢复经济和社会系统的同时,继续保护公民免受感染风险。这种新的情况需要所有利益相关者之间的积极合作:法定机构、雇主、民间社会和第三部门。