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Rev Paul Pediatr. 2020 Mar 16;38:e2019016. doi: 10.1590/1984-0462/2020/38/2019016. eCollection 2020.
2
Elevated Blood Pressure in Childhood or Adolescence and Cardiovascular Outcomes in Adulthood: A Systematic Review.儿童或青少年时期的高血压与成年期心血管结局:一项系统评价
Hypertension. 2020 Apr;75(4):948-955. doi: 10.1161/HYPERTENSIONAHA.119.14168. Epub 2020 Mar 2.
3
Cutoff values for HOMA-IR associated with metabolic syndrome in the Study of Cardiovascular Risk in Adolescents (ERICA Study).青少年心血管风险研究(ERICA研究)中与代谢综合征相关的HOMA-IR截断值。
Nutrition. 2020 Mar;71:110608. doi: 10.1016/j.nut.2019.110608. Epub 2019 Oct 11.
4
Global Prevalence of Hypertension in Children: A Systematic Review and Meta-analysis.全球儿童高血压患病率:系统评价和荟萃分析。
JAMA Pediatr. 2019 Dec 1;173(12):1154-1163. doi: 10.1001/jamapediatrics.2019.3310.
5
Characteristics of the school food environment associated with hypertension and obesity in Brazilian adolescents: a multilevel analysis of the Study of Cardiovascular Risks in Adolescents (ERICA).与巴西青少年高血压和肥胖相关的学校食物环境特征:青少年心血管风险研究(ERICA)的多层次分析。
Public Health Nutr. 2019 Oct;22(14):2625-2634. doi: 10.1017/S1368980019001010. Epub 2019 May 21.
6
Diet quality index for Brazilian adolescents: the ERICA study.巴西青少年饮食质量指数:ERICA 研究。
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7
Pathophysiology of essential hypertension: an update.原发性高血压的病理生理学:最新进展
Expert Rev Cardiovasc Ther. 2018 Dec;16(12):879-887. doi: 10.1080/14779072.2018.1540301.
8
Hypertension in Obesity and the Impact of Weight Loss.肥胖中的高血压及体重减轻的影响
Curr Cardiol Rep. 2017 Aug 24;19(10):98. doi: 10.1007/s11886-017-0912-4.
9
Glycated albumin: a potential biomarker in diabetes.糖化白蛋白:糖尿病中的一种潜在生物标志物。
Arch Endocrinol Metab. 2017 May-Jun;61(3):296-304. doi: 10.1590/2359-3997000000272.
10
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.氧化应激和活性氧在与心血管和代谢疾病相关的血管内皮功能障碍中的作用。
Vascul Pharmacol. 2018 Jan;100:1-19. doi: 10.1016/j.vph.2017.05.005. Epub 2017 Jun 1.

巴西联邦区学龄青少年的高血压及相关血脂、血糖和肥胖参数。

Hypertension and Associated Lipid, Glucose, and Adiposity Parameters in School-Aged Adolescents in the Federal District, Brazil.

机构信息

Departamento de Nutrição - Universidade de Brasília, Brasília, DF - Brasil.

Programa de Pós-graduação em Saúde Coletiva - Universidade de Brasília, Brasília, DF - Brasil.

出版信息

Arq Bras Cardiol. 2022 Apr;118(4):719-726. doi: 10.36660/abc.20201240.

DOI:10.36660/abc.20201240
PMID:35137784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9007003/
Abstract

BACKGROUND

The prevalence of hypertension and other metabolic disorders has increased in young individuals. However, no representative studies have been conducted in the population of the Federal District, Brazil.

OBJECTIVE

To estimate the prevalence of hypertension and its association with lipid, glucose, and adiposity markers in school-aged adolescents living in the Federal District.

METHODS

This cross-sectional study included participants of the Study of Cardiovascular Risks in Adolescents (Portuguese acronym, ERICA). Blood pressure, blood glucose, glycated hemoglobin, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, body mass index (BMI), waist circumference, and economic, demographic, and sexual maturity variables were assessed. The data were analyzed in Stata, and the analysis was divided into different stages: descriptive, crude, and adjusted. Significant results were set at p < 0.05.

RESULTS

In total, 1,200 adolescents were included, and their mean age was 14.8 years. The prevalence of hypertension was 8% (95% confidence interval: 6.3; 9.9). Most parameters were associated with blood pressure in crude analysis. In adjusted analysis, glucose, lipid, and adiposity markers maintained the associations, and the highest magnitudes were those of BMI and HOMA-IR.

CONCLUSION

The study revealed a high prevalence of hypertension in adolescents living in the Federal District, and blood pressure levels were associated with other markers of lipid, glucose, and adiposity profile. The findings indicate the relevance of health surveillance for planning effective actions aimed at reversing this situation and preventing new cases.

摘要

背景

高血压和其他代谢紊乱在年轻人中的患病率有所增加。然而,在巴西联邦区的人群中,尚未开展具有代表性的研究。

目的

评估在居住于巴西联邦区的青少年中,高血压的患病率及其与血脂、血糖和肥胖指标的相关性。

方法

本横断面研究纳入了心血管风险青少年研究(葡萄牙语缩写:ERICA)的参与者。评估了血压、血糖、糖化血红蛋白、胰岛素、稳态模型评估的胰岛素抵抗指数(HOMA-IR)、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白、体重指数(BMI)、腰围以及经济、人口统计学和性成熟变量。使用 Stata 软件分析数据,并将分析分为描述性、未校正和校正三个阶段。具有统计学意义的结果设定为 p < 0.05。

结果

共纳入了 1200 名青少年,平均年龄为 14.8 岁。高血压的患病率为 8%(95%置信区间:6.3%;9.9%)。在粗分析中,大多数参数与血压相关。在校正分析中,血糖、血脂和肥胖标志物与血压仍存在相关性,而 BMI 和 HOMA-IR 的相关性最强。

结论

本研究揭示了居住于巴西联邦区的青少年中高血压的高患病率,且血压水平与其他血脂、血糖和肥胖指标相关。这些发现表明,需要进行健康监测,以制定有效的行动规划,从而扭转这一局面并预防新的病例。