Universidade de Pernambuco, Programa de Pós-Graduação em Ciências da Saúde, Recife, Pernambuco, Brazil.
Universidade de Pernambuco, Pronto Socorro Cardiológico de Pernambuco, Ambulatório de Doença de Chagas e Insuficiência Cardíaca, Recife, Pernambuco, Brazil.
Rev Inst Med Trop Sao Paulo. 2022 Feb 2;64:e5. doi: 10.1590/S1678-9946202264005. eCollection 2022.
Chagas disease is among the 21 neglected diseases according to the World Health Organization. This study aimed to investigate the morbidity and mortality distribution of Chagas disease for identifying areas with greater prevalences and deaths of the disease in Northeast Brazil. A population-based ecological study was performed from 2016 to 2018 using data on acute Chagas disease patients from the Disease Notification Information System, chronic cases from the Chagas Disease and the referral Heart Failure Outpatient Clinic in Pernambuco, and Chagas disease-related mortality from the Mortality Information System. The unit of analysis were Pernambuco State mesoregions. The indicators were spatialized into thematic maps on the occurrence and mortality of the disease per 100,000 inhabitants. No cases of acute disease were reported in the period analyzed. Data on 801 chronic Chagas disease patients were analyzed. The population showed an average age of 62 years, with female predominance. The most prevalent comorbidity was systemic arterial hypertension and cardiologic involvement without ventricular dysfunction. The average chronic disease occurrence rate was 3.2/ 100,000 people/ year. As for deaths in the mortality system; in total, 350 deaths were recorded, showing male predominance, age ≥ 60 years, and chronic disease with cardiac involvement as the main mortality cause. The annual average mortality proportion was 1.6/100,000 people. The chronic case distribution showed spatial heterogeneity, with the highest rates of chronic disease and deaths observed in two mesoregions, with the main cause of death being heart-related. This highlights the need for more specialized services in areas with higher burden of the disease to avoid delay in the patients' care.
恰加斯病属于世界卫生组织 21 种被忽视的疾病之一。本研究旨在调查恰加斯病的发病率和死亡率分布，以确定巴西东北部发病率和死亡率较高的地区。这是一项基于人群的生态研究，使用了 2016 年至 2018 年期间来自疾病报告信息系统的急性恰加斯病患者数据、伯南布哥州恰加斯病和转诊心力衰竭门诊的慢性病例数据以及死亡率信息系统的恰加斯病相关死亡数据。分析单位为伯南布哥州的次区域。分析指标为每 10 万人中疾病发生和死亡的空间化专题地图。在分析期间未报告急性疾病病例。共分析了 801 例慢性恰加斯病患者的数据。人群的平均年龄为 62 岁，女性居多。最常见的合并症是全身性动脉高血压和无心室功能障碍的心脏受累。慢性疾病的平均年发生率为 3.2/100,000 人/年。在死亡率系统中，共记录了 350 例死亡，男性居多，年龄≥60 岁，慢性疾病伴有心脏受累是主要的死亡原因。年平均死亡率为 1.6/100,000 人。慢性病例的分布呈现出空间异质性，两个次区域的慢性疾病和死亡率最高，主要死亡原因是与心脏相关的疾病。这突显了需要在疾病负担较高的地区提供更多专业服务，以避免患者护理的延误。
