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长期接受胰岛素治疗的金黄仓鼠的饮食自我选择

Dietary self-selection in chronically insulin-treated golden hamsters.

作者信息

DiBattista D, Helm K J

出版信息

Behav Neurosci. 1986 Feb;100(1):129-32. doi: 10.1037//0735-7044.100.1.129.

DOI:10.1037//0735-7044.100.1.129
PMID:3513798
Abstract

Adult male golden hamsters were maintained on either Purina Rat Chow (chow group) or a self-selection diet consisting of high-protein chow, pure carbohydrate, and pure fat (choice group). Animals were injected for 12 consecutive days with either long-acting insulin (20 U/kg for 4 days, 60 U/kg for 4 days, and 100 U/kg for 4 days) or physiological saline. Insulin-injected hamsters under both dietary conditions increased their total caloric consumption by up to 33% and gained significantly more weight than saline-injected controls. Choice hamsters increased their fat intake in response to the 60 and 100 U/kg doses of insulin, but carbohydrate and protein consumption increased only in response to the 100 U/kg dose. Choice hamsters derived approximately 65% of the excess calories ingested during insulin administration from fat, but only 20% from carbohydrate and 15% from protein. Results are related to those previously observed in other species.

摘要

成年雄性金黄仓鼠分别喂食普瑞纳大鼠饲料(饲料组)或由高蛋白饲料、纯碳水化合物和纯脂肪组成的自选饮食(选择组)。连续12天给动物注射长效胰岛素(4天20 U/kg,4天60 U/kg,4天100 U/kg)或生理盐水。两种饮食条件下注射胰岛素的仓鼠总热量消耗增加了33%,体重增加显著高于注射生理盐水的对照组。选择组仓鼠在接受60和100 U/kg剂量胰岛素时脂肪摄入量增加,但碳水化合物和蛋白质消耗仅在接受100 U/kg剂量时增加。选择组仓鼠在注射胰岛素期间摄入的多余热量中约65%来自脂肪,仅20%来自碳水化合物,15%来自蛋白质。结果与之前在其他物种中观察到的结果相关。

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