几种新型苯并芘衍生物的无诱变性和推定致癌性
Lack of mutagenicity and putative carcinogenicity of several novel benzopyrene derivatives.
作者信息
Ashwood-Smith M J, Mitchell R H, Kennedy A
出版信息
Mutat Res. 1978 May;57(2):123-5. doi: 10.1016/0027-5107(78)90258-0.
PMID:351384
Abstract
Several novel benzopyrene derivatives with the same gross structure and the same electronic periphery as benzo(a)pyrene, but with some alteration in the complete electronic structure, when tested in the Ame's Salmonella/microsome test (TA 1537, TA 100 and TA 98], were found to lack mutagenicity and, therefore, putative carcinogenicity.
摘要
几种与苯并(a)芘具有相同总体结构和相同电子外围，但在完整电子结构上有一些改变的新型苯并芘衍生物，在艾姆斯沙门氏菌/微粒体试验（TA 1537、TA 100和TA 98）中进行测试时，被发现缺乏致突变性，因此也缺乏推定的致癌性。
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