Brain research Center and Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Adv Exp Med Biol. 2021;1349:355-370. doi: 10.1007/978-981-16-4254-8_16.
Ambient temperature detection and core body temperature maintenance are critical for the environment adaptability of mammals, requiring an elaborate neural network that converts the temperature information sensed by thermoreceptors into physiological and behavioral thermoregulatory responses. The molecular basis of thermosensation lies in the activation of various thermosensitive ion channels with distinct temperature thresholds expressed on the cell membrane of sensory neurons. These channels are able to convert thermal stimuli into electrical activities by gating ions into and out of the cell. In this chapter, we briefly introduce the physiological functions of the main thermosensitive ion channels involved in the core body temperature homeostasis orchestrated by the neural circuits in the peripheral and central nerve systems.
环境温度检测和核心体温维持对于哺乳动物的环境适应性至关重要，需要一个精细的神经网络，将热敏感受器感知到的温度信息转化为生理和行为性体温调节反应。温度感觉的分子基础在于激活各种热敏离子通道，这些通道在感觉神经元的细胞膜上表达，具有不同的温度阈值。这些通道能够通过离子进出细胞来将门控打开或关闭，从而将热刺激转化为电活动。在本章中，我们简要介绍了参与外周和中枢神经系统神经回路调节的核心体温稳态的主要热敏离子通道的生理功能。
