Vuk-Pavlović Z, Pavelić K, Vuk-Pavlović S
Blood. 1986 Apr;67(4):1031-5.
Murine myeloid leukemia secretes a substance immunochemically cross-reactive with insulin (SICRI) both in vivo and in serum-free media. High SICRI concentrations in peripheral blood of tumorous animals do not affect circulating glucose levels. In culture, DNA synthesis rate per leukemic cell is proportional to cell density and is reduced by antiinsulin serum. Culture medium conditioned by leukemia cells as well as SICRI affinity purified from this medium stimulate DNA synthesis in cultured leukemia cells. It appears that autocrine stimulation of murine myeloid leukemia can be mediated in part by an insulin-related growth factor.
小鼠髓性白血病在体内和无血清培养基中均分泌一种与胰岛素免疫化学交叉反应的物质（SICRI）。肿瘤动物外周血中高浓度的SICRI不会影响循环血糖水平。在培养中，每个白血病细胞的DNA合成速率与细胞密度成正比，并被抗胰岛素血清降低。白血病细胞条件培养基以及从该培养基中亲和纯化的SICRI可刺激培养的白血病细胞中的DNA合成。看来，小鼠髓性白血病的自分泌刺激可能部分由胰岛素相关生长因子介导。
