Heckler Ilana, Venkataraman Iswariya
Euroimmun US, Inc., Mountain Lakes, New Jersey.
J Neurophysiol. 2022 Mar 1;127(3):737-745. doi: 10.1152/jn.00398.2021. Epub 2022 Feb 9.
Neuroaxonal damage is a feature of various neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Phosphorylated neurofilament heavy chain (pNfH) is a cytoskeletal structural protein released as a result of axonal damage into the cerebrospinal fluid (CSF), and subsequently into the blood. Due to high specificity for neuronal cell damage, pNfH is advantageous over other biomarkers, for ALS disease identification. Here, we review the structure and function of neurofilaments and their role in detection of various neurodegenerative conditions. In addition, a retrospective meta-analysis was performed to depict the significance of pNfH as a valuable diagnostic and prognostic biomarker in ALS.
神经轴突损伤是包括肌萎缩侧索硬化症（ALS）在内的各种神经退行性疾病的一个特征。磷酸化神经丝重链（pNfH）是一种细胞骨架结构蛋白，由于轴突损伤而释放到脑脊液（CSF）中，随后进入血液。由于对神经元细胞损伤具有高度特异性，pNfH在识别ALS疾病方面比其他生物标志物更具优势。在这里，我们综述了神经丝的结构和功能及其在检测各种神经退行性疾病中的作用。此外，还进行了一项回顾性荟萃分析，以描述pNfH作为ALS中有价值的诊断和预后生物标志物的意义。
