School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands.
College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.
Appl Physiol Nutr Metab. 2022 May;47(5):547-554. doi: 10.1139/apnm-2021-0711. Epub 2022 Feb 9.
We aimed to assess the association between gastrointestinal (GI) injury, complaints, and food intake in 60-km ultramarathon runners. Thirty-three ultramarathon runners provided pre- and post-race blood samples for assessment of GI injury by intestinal fatty-acid binding protein (I-FABP), and inflammatory response by interleukin (IL)-6, IL-8, tumour necrosis factor alpha (TNF-α), and C-reactive protein (CRP). GI complaints and nutritional intake were reported by a post-race questionnaire. GI complaints were reported by 73% of the runners, of which 20% reported 1 or 2 severe complaints. IL-6, IL8, TNF-α, and CRP increased significantly from pre- to post-race ( < 0.001 for all biomarkers), while I-FABP did not (1375 [IQR: 1264-2073] to 1726 [IQR: 985-3287] pg/mL; = 0.330). The 'GI complaints score', as the integral of the number and severity of GI complaints, did not correlate with ΔI-FABP (rs: -0.050, = 0.790) or energy intake (rs: 0.211, = 0.260). However, there was a significant negative correlation between energy intake and ΔI-FABP (rs: -0.388, = 0.031). In conclusion, GI complaints were neither associated with food intake nor GI injury as assessed by plasma I-FABP response. Energy intake, however, was inversely related to the I-FABP response to exercise. This finding suggests that substantial energy intakes during exercise may prevent exercise-induced GI injury as assessed by the I-FABP response. No association between gastrointestinal complaints and gastrointestinal injury (I-FABP response) or food intake was present. There was an inverse correlation between energy intake and plasma I-FABP response, suggesting that higher energy intakes may prevent gastrointestinal injury as assessed by the I-FABP response.
我们旨在评估 60 公里超级马拉松运动员的胃肠道（GI）损伤、抱怨和食物摄入之间的关系。33 名超级马拉松运动员提供了比赛前后的血液样本，通过肠脂肪酸结合蛋白（I-FABP）评估 GI 损伤，通过白细胞介素（IL）-6、IL-8、肿瘤坏死因子-α（TNF-α）和 C 反应蛋白（CRP）评估炎症反应。GI 抱怨和营养摄入通过赛后问卷报告。73%的跑步者报告有 GI 抱怨，其中 20%报告有 1 或 2 种严重抱怨。IL-6、IL8、TNF-α和 CRP 从赛前到赛后显著增加（所有生物标志物均 < 0.001），而 I-FABP 没有（1375 [IQR：1264-2073] 至 1726 [IQR：985-3287] pg/mL； = 0.330）。作为 GI 抱怨数量和严重程度积分的“GI 抱怨评分”与 ΔI-FABP 无关（rs：-0.050， = 0.790）或能量摄入（rs：0.211， = 0.260）。然而，能量摄入与 ΔI-FABP 呈显著负相关（rs：-0.388， = 0.031）。总之，GI 抱怨既与食物摄入无关，也与血浆 I-FABP 反应评估的 GI 损伤无关。然而，能量摄入与运动引起的 I-FABP 反应呈负相关。这一发现表明，在运动过程中摄入大量能量可能会防止 I-FABP 反应评估的运动引起的胃肠道损伤。胃肠道抱怨与胃肠道损伤（I-FABP 反应）或食物摄入之间没有关联。能量摄入与血浆 I-FABP 反应呈负相关，表明较高的能量摄入可能会防止 I-FABP 反应评估的胃肠道损伤。
