Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, Gower Street, London, WC1E 6BT, UK.
Osteoarthritis Cartilage. 2022 Jun;30(6):802-814. doi: 10.1016/j.joca.2022.01.010. Epub 2022 Feb 6.
Osteoarthritis (OA) is a chronic degenerative joint disease and a leading cause of disability worldwide. Pain is the main symptom, yet no current treatment can halt disease progression or effectively provide symptomatic relief. Numerous animal models have been described for studying OA and some for the associated OA pain. This review aims to update on current models used for studying OA pain, focusing on mice and rats. These models include surgical, chemical, mechanical, and spontaneous OA models. The impact of sex and age will also be addressed in the context of OA modelling. Although no single animal model has been shown ideal for studying OA pain, increased efforts to phenotype OA will likely impact the choice of models for pre-clinical and basic research studies.
骨关节炎（OA）是一种慢性退行性关节疾病，也是全球致残的主要原因。疼痛是主要症状，但目前尚无任何治疗方法可以阻止疾病进展或有效缓解症状。已经描述了许多用于研究 OA 和相关 OA 疼痛的动物模型。本综述旨在更新目前用于研究 OA 疼痛的模型，重点是小鼠和大鼠。这些模型包括手术、化学、机械和自发性 OA 模型。还将讨论性别和年龄对 OA 建模的影响。尽管没有单一的动物模型被证明非常适合研究 OA 疼痛，但增加对 OA 表型的研究可能会影响临床前和基础研究中模型的选择。
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