Korochina K V
Orenburg State Medical University, Orenburg, Russia.
Bull Exp Biol Med. 2025 Aug 29. doi: 10.1007/s10517-025-06472-1.
The article examines the issue of sexual dimorphism in experimental non-traumatic osteoarthritis (OA). The study analyzed the articular structures and internal organs of 8-month-old female Wistar rats after inducing chronic heart failure and obesity, which served as the author's OA model. The results were compared with those from a control group of females and existing literature on OA modeling in males, using histochemical and morphometric techniques, as well as semi-quantitative assessments using the Mankin and OARSI scales and the Krenn synovitis scale. The findings indicate the onset of early OA in the experimental female group, supporting the effectiveness of this modeling approach based on vascular-metabolic factors. Additionally, the comparative analysis showed that joint tissue changes were more significant in males than in females, suggesting that male rats are more suitable for OA modeling.
本文探讨了实验性非创伤性骨关节炎（OA）中的性别二态性问题。该研究分析了诱导慢性心力衰竭和肥胖后的8个月龄雌性Wistar大鼠的关节结构和内脏器官，这些大鼠作为作者的OA模型。使用组织化学和形态计量学技术，以及使用曼金和OARSI量表以及克伦滑膜炎量表的半定量评估，将结果与雌性对照组以及关于雄性OA建模的现有文献进行了比较。研究结果表明实验雌性组出现了早期OA，支持了这种基于血管代谢因素的建模方法的有效性。此外，比较分析表明，雄性关节组织的变化比雌性更显著，这表明雄性大鼠更适合OA建模。
