School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW 2006, Australia.
Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 9808575, Japan.
J Biomech. 2022 Mar;133:110968. doi: 10.1016/j.jbiomech.2022.110968. Epub 2022 Jan 22.
To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up.
为了研究下颌骨切除术后的骨重塑反应，本文通过纳入患者特定的纵向数据，开发了一种联合外部和内部重塑算法。本研究的主要目的是通过与 28 个月的临床随访相关联，模拟腓骨游离皮瓣（FFF）重建后的结合区的骨重塑活动。本研究的次要目标是比较不同固定钢板设计与特定螺钉定位的长期结果。结果表明，除了对接部位（即 DS1，下颌联合处的感兴趣区域）外，整体骨密度随时间逐渐降低，DS1 处的骨密度下降较晚，随后出现骨沉积。不同螺钉定位对骨重塑结果的影响可以忽略不计。这项研究被认为是首例通过与患者特定的随访相关联，计算模拟 FFF 颌面重建后骨转换过程的研究。
