Soodmand Iman, Becker Ann-Kristin, Sass Jan-Oliver, Jabs Christopher, Kebbach Maeruan, Wanke Gesa, Dau Michael, Bader Rainer
Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Rostock, Germany.
Department of Oral, Maxillofacial Plastic Surgery, Rostock University Medical Center, Rostock, Germany.
Heliyon. 2024 Nov 30;10(24):e40668. doi: 10.1016/j.heliyon.2024.e40668. eCollection 2024 Dec 30.
Subject-specific finite element (FE) modeling of the mandible bone has recently gained attention for its higher accuracy. A critical modeling factor is including personalized material properties from medical images especially when bone quality has to be respected. However, there is no consensus on the material model for the mandible that realistically estimates the Young's modulus of the bone. Therefore, the present study aims to review FE studies employing heterogeneous material modeling of the human mandible bone, synthesizing these models, investigating their origins, and assessing their risk of bias. A systematic review using PRISMA guidelines was conducted on publications before 1 July 2024, involving PubMed, Scopus, and Web of Science. The search string considered (a) anatomical site (b) modeling strategy, and (c) metrics of interest. Two inclusion and five exclusion criteria were defined. A review of 77 FE studies identified 12 distinct heterogeneous material models, built based on different or computational methodologies leading to varied performance and highly deviated range of estimated Young's modulus. They are proposed for bones from five different anatomical sites than mandible and for both trabecular and cortical bone domains. The original studies were characterized with a low to medium risk of bias. This review assessed the current state of material modeling for subject-specific FE models in the craniomaxillofacial field. Recommendations are provided to support researchers in selecting density-modulus relationships. Future research should focus on standardizing experimental protocols, validating models through combined simulation and experimental approaches, and investigating the anisotropic behaviour of the mandible bone.
下颌骨的特定主体有限元（FE）建模因其更高的准确性最近受到了关注。一个关键的建模因素是纳入来自医学图像的个性化材料属性，尤其是在必须考虑骨质的情况下。然而，对于能实际估算骨杨氏模量的下颌骨材料模型尚无共识。因此，本研究旨在回顾采用人类下颌骨异质材料建模的有限元研究，综合这些模型，探究其来源，并评估其偏倚风险。使用PRISMA指南对2024年7月1日前的出版物进行了系统综述，涉及PubMed、Scopus和Web of Science。搜索词考虑了（a）解剖部位、（b）建模策略和（c）感兴趣的指标。定义了两条纳入标准和五条排除标准。对77项有限元研究的综述确定了12种不同的异质材料模型，这些模型基于不同的成像或计算方法构建，导致性能各异，估计的杨氏模量范围偏差很大。它们被提议用于下颌骨以外五个不同解剖部位的骨骼以及小梁骨和皮质骨区域。原始研究的偏倚风险为低到中度。本综述评估了颅颌面领域特定主体有限元模型材料建模的当前状态。提供了相关建议以支持研究人员选择密度 - 模量关系。未来的研究应专注于标准化实验方案，通过联合模拟和实验方法验证模型，并研究下颌骨的各向异性行为。
