Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Communication Sciences and Disorders, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
JDR Clin Trans Res. 2023 Apr;8(2):148-157. doi: 10.1177/23800844211072784. Epub 2022 Feb 10.
Markers of poor oral health are associated with impaired cognition and higher risk of Alzheimer disease (AD) and thus may help predict AD.
The aim of this study was to evaluate the cross-sectional association between empirically derived groups of 19 IgG antibodies against periodontal microorganisms and cognition in middle-aged and older adults.
The study population consisted of participants of the third National Health and Nutrition Examination Survey (NHANES III) (1988 to 1994), who were 60 y and older, among whom cognition and IgG antibodies against 19 periodontal microorganisms were measured ( = 5,162).
In multivariable quantile regression analyses, the Orange-Red (Prevotella melaninogenica, Prevotella intermedia, Prevotella nigrescens, Porphyromonas gingivalis) and Yellow-Orange (Staphylococcus intermedius, Streptococcus oralis, Streptococcus mutans, Fusobacterium nucleatum, Peptostreptococcus micros, Capnocytophaga ochracea) cluster scores were negatively associated with cognition. A 1-unit higher cluster score for the Orange-Red cluster was associated on average with a lower cognitive score (β for 30th quantile = -0.2640; 95% confidence interval [CI], -0.3431 to -0.1848). Similarly, a 1-unit higher score for the Yellow-Orange cluster was associated with a lower cognitive score (β for 30th quantile = -0.2445; 95% CI, -0.3517 to -0.1372).
Groups of IgG antibodies against periodontal microorganisms were associated with lower cognition among free living adults 60 years and older, who were previously undiagnosed with cognitive impairment. Though poor oral health precedes the development of dementia and AD, oral health information is currently not used, to our knowledge, to predict dementia or AD risk. Combining our findings with current algorithms may improve risk prediction for dementia and AD.
IgG antibodies against periodontal microorganisms were associated with lower cognition among adults 60 years and older previously undiagnosed with cognitive impairment. Periodontal disease may predict cognition among older adults.
口腔健康不良的标志物与认知功能受损以及更高的阿尔茨海默病（AD）风险相关，因此可能有助于预测 AD。
本研究旨在评估 19 种针对牙周微生物的 IgG 抗体经验衍生组与中年及老年人认知功能之间的横断面关联。
研究人群由第三次国家健康和营养检查调查（NHANES III）（1988 年至 1994 年）中的参与者组成，他们年龄在 60 岁及以上，其中测量了认知功能和针对 19 种牙周微生物的 IgG 抗体（=5162）。
在多变量分位数回归分析中，橙红色（普雷沃氏菌黑色素、中间普雷沃氏菌、黑色普雷沃氏菌、牙龈卟啉单胞菌）和黄橙色（中间葡萄球菌、口腔链球菌、变形链球菌、核梭杆菌、微消化链球菌、颗粒奈瑟菌）聚类评分与认知功能呈负相关。橙红色聚类评分每增加 1 个单位，平均认知评分就会降低（第 30 个分位数的β值为-0.2640；95%置信区间[CI]为-0.3431 至-0.1848）。同样，黄橙色聚类评分每增加 1 个单位，认知评分就会降低（第 30 个分位数的β值为-0.2445；95%CI 为-0.3517 至-0.1372）。
针对牙周微生物的 IgG 抗体组与 60 岁及以上未被诊断为认知障碍的自由生活成年人的认知功能较低相关。虽然口腔健康不良先于痴呆和 AD 的发展，但据我们所知，目前并未使用口腔健康信息来预测痴呆或 AD 风险。将我们的发现与当前的算法相结合，可能会提高对痴呆和 AD 的风险预测。
针对牙周微生物的 IgG 抗体与以前未被诊断为认知障碍的 60 岁及以上成年人的认知功能较低有关。牙周病可能可以预测老年人的认知功能。
