Goplerud J M, Delivoria-Papadopoulos M
Clin Perinatol. 1986 Mar;13(1):191-6.
Complex biochemical consequences are the result of a series of secondary biochemical changes caused by oxygen depletion. Hypoxia in the fetus and neonate results in decreased GI blood flow, especially to the GI mucosa. Although severe O2 deprivation cannot be entirely compensated for, an increase in tissue O2 extraction does occur in cases of moderate hypoxemia. In the neonate increased demands for O2 during feedings result in increased blood flow. The occurrence of hypoxia during feedings causes a decrease in intestinal motility, suggesting a clinical correlate to feeding intolerance and increased vulnerability to necrotizing enterocolitis.
复杂的生化后果是由缺氧引起的一系列继发性生化变化的结果。胎儿和新生儿缺氧会导致胃肠道血流减少，尤其是胃肠道黏膜的血流。尽管严重的氧气剥夺无法完全得到补偿，但在中度低氧血症的情况下，组织对氧气的摄取确实会增加。在新生儿中，喂养期间对氧气的需求增加会导致血流增加。喂养期间发生的缺氧会导致肠道蠕动减少，这表明与喂养不耐受以及坏死性小肠结肠炎易感性增加存在临床关联。
