Nowicki P T, Hansen N B, Oh W, Stonestreet B S
Pediatr Res. 1984 May;18(5):420-5. doi: 10.1203/00006450-198405000-00005.
The purpose of this study was to investigate the compensatory change in circulation and oxygenation of the newborn lamb gastrointestinal (GI) tract in response to anemic and hypoxic hypoxemia. Radiolabeled microspheres were used to measure blood flow. We subjected the newborn lamb to a 30-35% reduction in hematocrit 4 d before study and to a 10% oxygen environment for 30 min during the study to induce chronic anemic and acute hypoxic hypoxemia, respectively. The circulatory and oxygenation responses were measured 1 h after a standard milk feeding in all cases. During the experimental periods, no change in total GI blood flow was observed. Because of a failure to augment blood flow during hypoxemia, O2 delivery to the GI tract decreased significantly. Despite this, GI O2 consumption was not compromised because tissue O2 extraction by the GI tract rose significantly. The response of the newborn lamb GI tract to hypoxemia after feeding is augmentation of O2 extraction. The newborn's GI tract did not regulate local GI blood flow.
本研究的目的是调查新生羔羊胃肠道（GI）循环和氧合对贫血性和低氧性低氧血症的代偿性变化。使用放射性标记微球测量血流量。在研究前4天，我们使新生羔羊的血细胞比容降低30 - 35%，并在研究期间将其置于10%氧气环境中30分钟，分别诱导慢性贫血和急性低氧性低氧血症。在所有情况下，均在标准喂奶1小时后测量循环和氧合反应。在实验期间，未观察到胃肠道总血流量的变化。由于低氧血症期间未能增加血流量，胃肠道的氧气输送显著减少。尽管如此，胃肠道的氧气消耗并未受到影响，因为胃肠道的组织氧摄取显著增加。新生羔羊胃肠道喂食后对低氧血症的反应是氧摄取增加。新生羔羊的胃肠道并未调节局部胃肠道血流量。
