Bwambale Phenehas, Yahaya James J, Owor Geraldine, Wabinga Henry
Department of Pathology, Makerere College of Health Sciences, Kampala, Uganda.
Department of Histopathology and Morbid Anatomy, School of Medicine and Dentistry, The University of Dodoma, Dodoma, Tanzania.
J Taibah Univ Med Sci. 2021 Nov 3;17(1):96-104. doi: 10.1016/j.jtumed.2021.09.007. eCollection 2022 Feb.
This study aims to determine the histopathological patterns and biological characteristics of ameloblastoma.
This was a cross-sectional retrospective laboratory-based study using 82 formalin-fixed paraffin-embedded tissue blocks from patients diagnosed histologically with ameloblastoma. Information regarding age, sex, anatomical location of the lesion, histopathologic type, and biological behaviour or characteristics of the types of ameloblastoma was obtained from laboratory request forms. Categorical and continuous variables were summarized in percentage and mean ± standard deviation, respectively. The cohort was conducted on Ugandan patients diagnosed between 2016 and 2019.
Most patients (66.3%) were clinically presenting a painless jaw swelling, and a follicular pattern was common (39%) followed by the plexiform pattern (12.2%). All the ameloblastoma cases (100%) were benign, with the majority (76.8%) cases being non-recurrent while the remaining (23.2%) were recurrent, and the plexiform pattern was the commonest recurrent histopathological pattern.
This study reports a relatively significant rate of recurrence in almost a quarter of the study population. The plexiform histopathologic type was the dominant type in recurrence cases. Therefore, this finding provides insightful information to clinicians to ensure close follow-up for patients diagnosed with such a variant to prevent possible relapse of the disease.
本研究旨在确定成釉细胞瘤的组织病理学模式和生物学特征。
这是一项基于实验室的横断面回顾性研究，使用了82个经福尔马林固定、石蜡包埋的组织块，这些组织块来自组织学诊断为成釉细胞瘤的患者。有关年龄、性别、病变的解剖位置、组织病理学类型以及成釉细胞瘤类型的生物学行为或特征的信息，是从实验室申请表中获取的。分类变量和连续变量分别以百分比和均值±标准差进行汇总。该队列研究的对象是2016年至2019年间诊断出的乌干达患者。
大多数患者（66.3%）临床上表现为无痛性颌骨肿胀，滤泡型常见（39%），其次是丛状型（12.2%）。所有成釉细胞瘤病例（100%）均为良性，大多数（76.8%）病例无复发，其余（23.2%）为复发病例，丛状型是最常见的复发组织病理学类型。
本研究报告了近四分之一的研究人群中复发率相对较高。丛状组织病理学类型是复发病例中的主要类型。因此，这一发现为临床医生提供了有价值的信息，以确保对诊断为此类变体的患者进行密切随访，防止疾病可能复发。
