Saghravanian Nasrollah, Salehinejad Jahanshah, Ghazi Narges, Shirdel Mohammad, Razi Mahsa
Oral and Maxillofacial Diseases Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran E-mail :
Asian Pac J Cancer Prev. 2016;17(2):619-23. doi: 10.7314/apjcp.2016.17.2.619.
Ameloblastoma is the most common epithelial odontogenic tumor. It may show locally invasive behavior resulting in recurrence and malignancy. Therefore, appropriate diagnosis of this tumor is necessary. The aim of this study was to evaluate clinicopathological characteristics of ameloblastomas in an Iranian population. We present a 40-year retrospective study of patients diagnosed from 1971 to 2010 in the Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mashhad, Iran. Information gathered from patient records included age, gender, tumor location and histologic type. The frequency of odontogenic tumors among all lesions was 2.08% and ameloblastoma with 88 samples demonstrated the greatest prevalence (41.5%). Regarding gender, 60% of samples occurred in males. The mean age of studied patients was 33.02± 15.74 years with a peak of occurrence in the third decade of life. The most frequent location of tumor was the mandibles (93.2%). Eighty five (96.6%) tumors were recorded as benign and 3 (3.4%) as malignant. Of benign tumors, 62 (72.9%), 20 (23.5%) and 3 (3.6%) cases were of conventional, unicyctic and peripheral types, respectively. In contrast to most previous studies, the most common histologic subtype in the present study was plexiform. Knowledge of the incidence of ameloblastoma and its clinicopathologic features including most common location, gender and age distribution in different ethnogeographic backgrounds is necessary for accurate diagnosis and proper treatment.
成釉细胞瘤是最常见的上皮性牙源性肿瘤。它可能表现出局部侵袭性行为，导致复发和恶变。因此，对该肿瘤进行准确诊断很有必要。本研究的目的是评估伊朗人群中成釉细胞瘤的临床病理特征。我们对1971年至2010年在伊朗马什哈德牙科学院口腔颌面病理学系诊断的患者进行了一项为期40年的回顾性研究。从患者记录中收集的信息包括年龄、性别、肿瘤位置和组织学类型。所有病变中牙源性肿瘤的发生率为2.08%，88例成釉细胞瘤样本的患病率最高（41.5%）。在性别方面，60%的样本发生在男性。研究患者的平均年龄为33.02±15.74岁，发病高峰在生命的第三个十年。肿瘤最常见的部位是下颌骨（93.2%）。85例（96.6%）肿瘤被记录为良性，3例（3.4%）为恶性。在良性肿瘤中，传统型、单囊型和外周型分别有62例（72.9%）、20例（23.5%）和3例（3.6%）。与大多数先前的研究不同，本研究中最常见的组织学亚型是丛状型。了解成釉细胞瘤的发病率及其临床病理特征，包括不同种族地理背景下最常见的部位、性别和年龄分布，对于准确诊断和恰当治疗是必要的。
