Reikerås O, Gunnes P
Clin Physiol. 1986 Apr;6(2):129-38. doi: 10.1111/j.1475-097x.1986.tb00061.x.
This study describes the effects of a wide range of plasma concentrations of insulin on systemic haemodynamics and free fatty acids (FFA) and the effect of a high dose of insulin on regional blood flows in the femoral, carotid, mesenteric and renal arteries. Insulin was infused in 10 dogs at rates of 4, 8, 16, 32, 64 and 128 IU/kg/h, and the experiments were concluded with a bolus injection of 300 IU. Plasma glucose concentrations were kept constant during the experiments. A dose-related increase in maximum rate of left ventricular pressure rise, stroke volume and cardiac output, and decrease in total peripheral resistance was found with insulin infusion rates up to 64 IU/kg/h. Heart rate and mean aortic blood-pressure were unchanged. The maximum antilipolytic effect was obtained at an infusion rate of 16 IU/kg/h. Insulin was given as a bolus dose of 300 IU in 6 dogs. Blood-flow was increased in all vascular beds, but insulin caused a redistribution of cardiac output. The greatest increases occurred in the femoral and carotid vascular beds, and the least occurred in the renal bed. Mesenteric blood-flow was increased in proportion to cardiac output. The results suggest that insulin exerts combined positive inotropic and vasodilating effects at high dose levels, which result in improved regional perfusion. It may be a potentially useful clinical agent with special benefit under circumstances where enhanced cerebral blood-flow is of importance.
本研究描述了多种血浆胰岛素浓度对全身血流动力学和游离脂肪酸（FFA）的影响，以及高剂量胰岛素对股动脉、颈动脉、肠系膜动脉和肾动脉局部血流的影响。对10只狗以4、8、16、32、64和128 IU/kg/h的速率输注胰岛素，并在实验结束时推注300 IU。实验期间血浆葡萄糖浓度保持恒定。发现胰岛素输注速率高达64 IU/kg/h时，左心室压力上升最大速率、每搏输出量和心输出量呈剂量相关增加，总外周阻力降低。心率和平均主动脉血压未改变。在输注速率为16 IU/kg/h时获得最大抗脂解作用。对6只狗给予300 IU的胰岛素推注剂量。所有血管床的血流量均增加，但胰岛素导致心输出量重新分布。股动脉和颈动脉血管床增加最大，肾血管床增加最小。肠系膜血流量与心输出量成比例增加。结果表明，胰岛素在高剂量水平发挥正性肌力和血管舒张的联合作用，从而改善局部灌注。在脑血流量增加很重要的情况下，它可能是一种潜在有用的临床药物，具有特殊益处。
