Xu Tao, He Bangshun, Sun Huiling, Xiong Mengqiu, Nie Junjie, Wang Shukui, Pan Yuqin
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Department of Laboratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Mol Ther Nucleic Acids. 2022 Jan 10;27:824-837. doi: 10.1016/j.omtn.2022.01.007. eCollection 2022 Mar 8.
As the most prevalent type of RNA modification in eukaryotes, N6-methyladenosine (mA) can modulate RNA fates such as processing, splicing, maturation, export, stability, translation, and degradation. Circular RNAs (circRNAs), a novel type of non-coding RNA (ncRNAs) characterized by a covalently closed loop structure, play an essential role in various physiological and pathological processes. Extensive studies have revealed that mA modification is widespread in circRNAs and influences their biogenesis and functions. Intriguingly, circRNAs can affect mA modification by regulating mA regulatory proteins. In this review, we summarize the characteristics and biological functions of mA and circRNAs and focus on recent advances in the interaction of mA modification and circRNAs. In addition, the potential clinical applications of mA modification and circRNAs in diagnosis and therapeutic targets are discussed.
作为真核生物中最普遍的RNA修饰类型，N6-甲基腺苷（m6A）可以调节RNA的命运，如加工、剪接、成熟、输出、稳定性、翻译和降解。环状RNA（circRNA）是一种新型的非编码RNA（ncRNA），其特征在于共价闭环结构，在各种生理和病理过程中发挥着重要作用。广泛的研究表明，m6A修饰在circRNA中广泛存在，并影响其生物合成和功能。有趣的是，circRNA可以通过调节m6A调节蛋白来影响m6A修饰。在这篇综述中，我们总结了m6A和circRNA的特征及生物学功能，并重点关注m6A修饰与circRNA相互作用的最新进展。此外，还讨论了m6A修饰和circRNA在诊断和治疗靶点方面的潜在临床应用。
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