Mehmood Rashid
Department of Life Sciences, College of Science and General Studies, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.
Curr Genomics. 2024 May 31;25(3):158-170. doi: 10.2174/0113892029296712240405053201. Epub 2024 Apr 9.
N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing, export, translation, and stability of the modified mRNA. Recent evidence suggests that various classes of non- coding RNAs (ncRNAs), including microRNAs (miRNAs), circular RNAs (circRNAs), and long con-coding RNAs (lncRNAs), are also targeted by this modification. Depending on the ncRNA species, m6A may affect the processing, stability, or localization of these molecules. The m6A- modified ncRNAs are implicated in a number of diseases, including cancer. In this review, the author summarizes the role of mA modification in the regulation and functions of ncRNAs in tumor development. Moreover, the potential applications in cancer prognosis and therapeutics are discussed.
N6-甲基腺苷（m6A）是一种RNA修饰，其中腺苷的N6位被甲基化。它是RNA最普遍的内部修饰之一，调节RNA代谢的各个方面。m6A由m6A甲基转移酶沉积，由m6A去甲基化酶去除，并被读取蛋白识别，这些蛋白调节修饰后mRNA的剪接、输出、翻译和稳定性。最近的证据表明，包括微小RNA（miRNA）、环状RNA（circRNA）和长链非编码RNA（lncRNA）在内的各类非编码RNA（ncRNA）也受到这种修饰的靶向作用。根据ncRNA的种类，m6A可能会影响这些分子的加工、稳定性或定位。m6A修饰的ncRNA与包括癌症在内的多种疾病有关。在这篇综述中，作者总结了m6A修饰在肿瘤发生过程中对ncRNA的调控作用及功能。此外，还讨论了其在癌症预后和治疗中的潜在应用。
