Hu Yongfei
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Sheng Wu Gong Cheng Xue Bao. 2022 Jan 25;38(1):104-118. doi: 10.13345/j.cjb.210377.
Alginate is a group of polyuronic saccharides that are widely used in pharmaceutical and food industry due to its unique physicochemical properties and beneficial health effects. However, the low water solubility and high viscosity of alginate hampered its application. Alginate oligosaccharide (AOS) is a decomposition product of alginate and has received increasing attention due to its low molecular weight, high water solubility, safety, and non-toxicity. The wide-ranging biological functions of AOS are closely related to its structural diversity. AOS with distinct structures and biological functions can be obtained by different methods of preparation. This review summarized the biological functions of AOS reported to date, including anti-tumor, immunomodulatory, anti-inflammatory, antioxidant, prebiotic, and anti-diabetes. The preparation of AOS, as well as the relationship between the structure and biological functions of AOS were discussed, with the aim to provide a reference for further development and application of AOS.
海藻酸盐是一类聚糖醛酸糖类，因其独特的理化性质和有益的健康效应而被广泛应用于制药和食品工业。然而，海藻酸盐的低水溶性和高粘度阻碍了其应用。海藻寡糖（AOS）是海藻酸盐的分解产物，由于其分子量低、水溶性高、安全无毒而受到越来越多的关注。AOS广泛的生物学功能与其结构多样性密切相关。通过不同的制备方法可以获得具有不同结构和生物学功能的AOS。本文综述了迄今为止报道的AOS的生物学功能，包括抗肿瘤、免疫调节、抗炎、抗氧化、益生元及抗糖尿病等。讨论了AOS的制备方法以及AOS的结构与生物学功能之间的关系，旨在为AOS的进一步开发和应用提供参考。
