临床实验室儿童凝血酶原时间和活化部分凝血活酶时间参考区间的验证和建立。
Verification and Establishment of Reference Intervals for Prothrombin Time and Activated Partial Thromboplastin Time for Children in a Clinical Laboratory.
出版信息
Clin Lab. 2022 Feb 1;68(2). doi: 10.7754/Clin.Lab.2021.210539.
BACKGROUND
Prothrombin time (PT) and activated partial thromboplastin time (aPTT) are routine coagulation tests. The absence of age-dependent reference interval (RI) may lead to abnormal results in children. In this study, we aimed to verify adult-based RIs in children and establish pediatric RIs for PT and aPTT.
METHODS
We analyzed PT and aPTT results. Samples from inpatients and outpatients aged 1 - 18 years, considered healthy subjects, were divided into six groups by age. Verification and establishment of RIs were conducted.
RESULTS
Applying adult-based RIs to pediatrics was statistically invalid for individuals aged 10 - 18 years for PT and invalid throughout childhood for aPTT. The new RI of PT for individuals aged 10 - 18 years was 11.1 - 14.1 seconds and that of aPTT for individuals aged 1 - 9 years was 28.2 - 46.0 seconds.
CONCLUSIONS
Pediatric RIs were higher than adult-based RIs. Using pediatric RI can save time, labor, and costs to make clinical decision.
背景
凝血酶原时间（PT）和活化部分凝血活酶时间（aPTT）是常规凝血检测。缺乏年龄依赖性参考区间（RI）可能导致儿童的检测结果异常。在本研究中，我们旨在验证儿童的成人基础 RI，并建立 PT 和 aPTT 的儿科 RI。
方法
我们分析了 PT 和 aPTT 的结果。将年龄在 1 至 18 岁、被认为是健康受试者的住院和门诊患者的样本分为 6 组，按年龄分组。对 RI 进行了验证和建立。
结果
将成人 RI 应用于儿科，对于 10 至 18 岁的个体，PT 的 RI 统计上无效，而对于整个儿童时期，aPTT 的 RI 无效。10 至 18 岁个体的 PT 新 RI 为 11.1-14.1 秒，1 至 9 岁个体的 aPTT 新 RI 为 28.2-46.0 秒。
结论
儿科 RI 高于成人基础 RI。使用儿科 RI 可以节省时间、劳动力和成本来做出临床决策。
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