生长中的兔耳动脉去神经后内皮介导的舒张功能改变。
Altered endothelium-mediated relaxation after denervation of growing rabbit ear artery.
作者信息
Mangiarua E I, Bevan R D
出版信息
Eur J Pharmacol. 1986 Mar 11;122(1):149-52. doi: 10.1016/0014-2999(86)90172-x.
The relaxation response to methacholine and sodium nitroprusside was examined in ring segments from the posterior auricular artery and its continuation the central ear artery in growing rabbits 2, 4, 6 and 8 weeks following unilateral adrenergic and sensory denervation. The maximal relaxation achieved by methacholine (endothelium-dependent) was significantly depressed in the denervated arteries compared with the contralateral controls. Sodium nitroprusside (endothelium-independent relaxant agent) elicited the maximal relaxation in all tissues. These results demonstrated impaired arterial endothelium-dependent relaxation to methacholine after chronic denervation.
在单侧去甲肾上腺素能和感觉神经去支配后2周、4周、6周和8周的生长兔中，检测耳后动脉及其延续的中耳动脉环段对乙酰甲胆碱和硝普钠的舒张反应。与对侧对照相比，去神经支配动脉中乙酰甲胆碱（内皮依赖性）实现的最大舒张显著降低。硝普钠（非内皮依赖性舒张剂）在所有组织中引起最大舒张。这些结果表明，慢性去神经支配后动脉对乙酰甲胆碱的内皮依赖性舒张受损。
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