载脂蛋白 E 基因型、海马体与美洲印第安人阿尔茨海默病的认知标志物：来自“强壮心灵研究”的数据。
APOE genotype, hippocampus, and cognitive markers of Alzheimer's disease in American Indians: Data from the Strong Heart Study.
机构信息
Washington State University Elson S Floyd College of Medicine, Seattle, Washington, USA.
MedStar Health Research Institute, Phoenix, Arizona, USA.
出版信息
Alzheimers Dement. 2022 Dec;18(12):2518-2526. doi: 10.1002/alz.12573. Epub 2022 Feb 10.
Abstract
BACKGROUND
The apolipoprotein E (APOE) ε4 allele confers higher risk of neurodegeneration and Alzheimer's disease (AD), but differs by race/ethnicity. We examined this association in American Indians.
METHODS
The Strong Heart Study is a population-based cohort of American Indians who were 64 to 95 years of age in 2010 to 2013. APOE ε4 status, brain imaging, and neuropsychological testing was collected in N = 811 individuals. Summary statistics, graphics, and generalized linear regressions-adjusted for sociodemographics, clinical features, and intracranial volume with bootstrap variance estimator-compared APOE ε4 carriers with non-carriers.
RESULTS
APOE ε4 carriers comprised 22% of the population (0.7% homozygotes). Participants were mean 73 years, 67% female, and 54% had some college education. The majority were obese (>50%), hypertensive (>80%), and diabetic (>50%). Neither imaging findings nor multidomain cognitive testing showed any substantive differences between APOE ε4 carriers and non-carriers.
CONCLUSION
We found no evidence of neurodegenerative risk from APOE ε4 in American Indians. Additional studies are needed to examine potential protective features.
摘要
背景
载脂蛋白 E（APOE）ε4 等位基因增加了神经退行性变和阿尔茨海默病（AD）的风险，但存在种族/民族差异。我们在美国印第安人中研究了这种关联。
方法
“强心研究”是一项基于人群的美国印第安人队列研究，参与者在 2010 年至 2013 年时年龄在 64 至 95 岁之间。共收集了 811 名参与者的 APOE ε4 状态、脑成像和神经心理学测试数据。使用广义线性回归（调整了社会人口统计学、临床特征和颅内体积，并使用自举方差估计器进行了校正），比较了 APOE ε4 携带者和非携带者的情况，生成了汇总统计信息、图形和结果。
结果
APOE ε4 携带者占人群的 22%（0.7%为纯合子）。参与者的平均年龄为 73 岁，67%为女性，54%接受过一些大学教育。大多数参与者肥胖（>50%）、高血压（>80%）和糖尿病（>50%）。APOE ε4 携带者和非携带者之间的影像学发现或多领域认知测试均无明显差异。
结论
我们未发现 APOE ε4 在美国印第安人中具有神经退行性风险的证据。需要进一步研究以检查潜在的保护特征。
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2
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3
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6
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8
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