Karpus Andrii, Mignani Serge, Zablocka Maria, Majoral Jean Pierre
Laboratoire de Chimie de Coordination (LCC), CNRS, 205 route de Narbonne, Toulouse Cedex 4 31077, France.
LCC-CNRS Université de Toulouse, 118 route de Narbonne, Toulouse Cedex 4 31077, France.
J Org Chem. 2022 Mar 4;87(5):3433-3441. doi: 10.1021/acs.joc.1c03009. Epub 2022 Feb 10.
Phosphorus dendrimers are used for many applications in different domains including nanomedicine as cargo of drugs or as species active but also in a variety of other fields ranging from nanoscience to catalysis. Their properties depend on the nature of their internal structure and mainly of the diversity and versatility of the functional groups located on their outer shell. Therefore, there is a need to diversify their structure in order to use them for new applications and to propose alternative synthetic pathways to be built easily, at each step and in high yield a family of original stable phosphorus dendrimers of different generations. Such a goal is illustrated in this report with the original synthesis of 14 new phosphorus dendrimers of generation 0 to 2 and the possibility to modify at will their internal structure and the nature of their functional end groups.
磷树枝状大分子在不同领域有许多应用，包括在纳米医学中作为药物载体或活性物质，也应用于从纳米科学到催化等各种其他领域。它们的性质取决于其内部结构的性质，主要取决于位于其外壳上的官能团的多样性和多功能性。因此，有必要使其结构多样化，以便将它们用于新的应用，并提出易于构建的替代合成途径，在每一步都能高产率地合成出一系列不同代数的新型稳定磷树枝状大分子。本报告通过成功合成14种从第0代到第2代的新型磷树枝状大分子以及随意修饰其内部结构和官能端基性质的可能性，阐述了这一目标。
