Department of Physiology and Pharmacology, Graduated Program in Pharmacology, Federal University of Santa Maria (Ufsm), Santa Maria (RS), Brazil.
Expert Rev Neurother. 2022 Mar;22(3):257-268. doi: 10.1080/14737175.2022.2041414. Epub 2022 Feb 28.
Primary headache disorders, such as migraine and tension-type headache (TTH), represent a significant public health concern. Besides, cognitive/mental stress was suggested to contribute to TTH and migraine physiopathology. Thus, this study aimed to evaluate the existence of a causal relationship between stress (mental/cognitive or daily stress) and headache or pain improvement in migraine and TTH patients.
We developed a systematic review of the literature, including studies that utilized mental/cognitive stress tasks or daily stress by lifestyle questionnaire in migraine and TTH patients. Necessarily, these studies should have healthy patients and a pain measure (quantitative sensory tests or headache/migraine detection). PubMed, EMBASE, and SCOPUS were searched, using terms about stress and primary headaches.
Both mental/cognitive stress and daily stress (perceived) were related to an increase in pain perception and related to the development of headache or enhanced transient pain intensity in migraine and TTH patients. Different factors could enrich the comprehension of the influence of stress on pain/headache induction in migraine and TTH patients, including methodological standardization, consistency of assessing, and isolating the many headache triggers in randomized controlled trial studies.
原发性头痛障碍,如偏头痛和紧张型头痛(TTH),是一个重大的公共卫生关注点。此外,认知/精神压力被认为与 TTH 和偏头痛的病理生理学有关。因此,本研究旨在评估精神/认知压力(精神/认知压力或日常生活压力)与偏头痛和 TTH 患者头痛或疼痛改善之间是否存在因果关系。
我们对文献进行了系统综述,包括在偏头痛和 TTH 患者中使用精神/认知压力任务或日常生活压力生活方式问卷的研究。这些研究必须有健康患者和疼痛测量(定量感觉测试或头痛/偏头痛检测)。使用有关压力和原发性头痛的术语,在 PubMed、EMBASE 和 SCOPUS 中进行了搜索。
精神/认知压力和日常生活压力(感知到的)都与疼痛感知增加有关,并与偏头痛和 TTH 患者头痛或短暂性疼痛强度增强有关。包括方法学标准化、评估一致性和在随机对照试验研究中隔离许多头痛触发因素在内的不同因素,可以丰富对压力对偏头痛和 TTH 患者疼痛/头痛诱发影响的理解。