Department of Rehabilitation Medicine, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Shichang west road 1399, Wujiang District, Suzhou, 215228, Jiangsu, China.
Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Sci Rep. 2024 Oct 12;14(1):23901. doi: 10.1038/s41598-024-74745-2.
Researchers have conducted extensive research on the correlation between brain resting-state functional activities (RSFA) and migraine. However, we still do not fully understand the exact nature of the causal relationship between these RSFA and migraine. We conducted a bidirectional two-sample Mendelian randomization (MR) study to investigate the causal association between migraine and RSFA. We gathered summary statistics from genome-wide association studies for 191 resting-state functional magnetic resonance imaging phenotypes. We employed various analytical methods for bidirectional two-sample MR analyses. This included inverse variance weighted, weighted median, MR Egger, and the constrained maximum likelihood approaches. We also conducted pleiotropy and heterogeneity analyses to evaluate the robustness and reliability. We found the functional connectivity between the default mode and the central executive network (OR = 1.39, p = 4.77 × 10, FDR corrected p value = 0.040) and the intensity of spontaneous brain activity in the calcarine or lingual gyrus within the visual network (OR = 0.74, p = 5.94 × 10, FDR corrected p value = 0.040) having a causal effect on the risk of migraine. Our MR analysis provided genetic support for these networks, which may play an important role in influencing migraine susceptibility.
研究人员对大脑静息态功能活动（RSFA）与偏头痛之间的相关性进行了广泛的研究。然而，我们仍然不完全了解这些 RSFA 与偏头痛之间因果关系的确切性质。我们进行了一项双向双样本 Mendelian 随机化（MR）研究，以调查偏头痛与 RSFA 之间的因果关联。我们从全基因组关联研究中收集了 191 个静息态功能磁共振成像表型的汇总统计数据。我们采用了各种双向双样本 MR 分析方法，包括逆方差加权、加权中位数、MR Egger 和约束最大似然方法。我们还进行了多效性和异质性分析，以评估稳健性和可靠性。我们发现默认模式和中央执行网络之间的功能连接（OR = 1.39，p = 4.77×10，FDR 校正 p 值 = 0.040）以及视觉网络中内囊或舌回的自发脑活动强度（OR = 0.74，p = 5.94×10，FDR 校正 p 值 = 0.040）对偏头痛的风险有因果影响。我们的 MR 分析为这些网络提供了遗传支持，这些网络可能在影响偏头痛易感性方面发挥重要作用。
