State Key Laboratory of Fine Chemicals, Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China.
Inorg Chem. 2022 Feb 21;61(7):3132-3140. doi: 10.1021/acs.inorgchem.1c03412. Epub 2022 Feb 10.
Adenosine triphosphate (ATP) is an important kind of metabolized biological molecule that is formed in organisms, especially in mitochondria, is used universally as energy, and is one of the most significant multifunctional biological molecules. Metal-organic frameworks (MOFs) have been widely used in many applications such as gas storage and separation, drug delivery, heterogeneous catalysis, chemical sensors, etc. Remarkably, lanthanide MOFs (Ln-MOFs), which display large pores, multiple dimensions, and unique lanthanide luminescence properties, are widely used as chemical sensors. A novel three-dimensional probe, Eu(sbdc)(HO) (Eu-sbdc), was successfully self-assembled with Eu(NO)·6HO and 5,5-dioxo-5-dibenzo[,]thiophene-3,7-dicarboxylic acid (Hsbdc). The Ln-MOF Eu-sbdc can quickly and effectively optically detect ATP via a luminescent quenching mechanism. The value of Eu-sbdc is 1.02 × 10 M, and the lower detection limit of Eu-sbdc for ATP is 20 μM, which is more sensitive to ATP. Its mechanism of monitoring ATP might be a dynamic or static quenching process. Eu-sbdc could effectively and quickly recognize ATP with high sensitivity.
三磷酸腺苷（ATP）是一种重要的代谢生物分子，在生物体中形成，特别是在线粒体中，被普遍用作能量，是最重要的多功能生物分子之一。金属有机骨架（MOFs）已广泛应用于气体储存和分离、药物输送、多相催化、化学传感器等许多应用。值得注意的是，具有大孔、多维和独特镧系元素发光特性的镧系 MOFs（Ln-MOFs）被广泛用作化学传感器。一种新型的三维探针 Eu(sbdc)(HO)（Eu-sbdc），Eu(NO)·6HO 和 5,5-二氧代-5-二苯并[,]噻吩-3,7-二羧酸（Hsbdc）成功地自组装而成。Ln-MOF Eu-sbdc 通过发光猝灭机制可以快速有效地光学检测 ATP。Eu-sbdc 的 值为 1.02×10 M，Eu-sbdc 对 ATP 的检测下限为 20 μM，对 ATP 的检测更灵敏。其监测 ATP 的机制可能是动态或静态猝灭过程。Eu-sbdc 可以有效地、快速地、高灵敏度地识别 ATP。
