Clinical efficacy and safety of the Jinfeng pill in the adjuvant treatment of infertility in patients with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trial.

BACKGROUND

Polycystic ovary syndrome (PCOS) is a common endocrine disease leading to infertility in women of childbearing age. Adjuvant therapy with Jinfeng pills (a traditional Chinese medicine) can increase ovarian blood flow, regulate female endocrine levels, and achieve good therapeutic effect. A systematic review and meta-analysis were conducted to examine the efficacy and safety of Jinfeng pills.

METHODS

The PubMed (2000 to August 2021), Excerpta Medica Database (2000 to August 2021), Chinese Biomedical Literature (2000 to August 2021), and China National Knowledge Infrastructure (2000 to August 2021) databases were searched. All patients with PCOS were included in the randomized controlled study of Jinfeng pills combined with an adjuvant Western medicine treatment. After screening and a risk of bias assessment, Stata16.0 software was used for the analysis.

RESULTS

A total 7 of articles (comprising 691 patients; 26-83 participants per group) were included in the meta-analysis. The meta-analysis showed that the effective rate the experimental group treated with Jinfeng pills combined with adjuvant Western medicine was higher than that of the control group treated with Western medicine only [relative risk (RR) =1.15, 95% confidence interval (CI): 1.03 to 1.28; P=0.015]. After treatment, the follicle-stimulating hormone level of the experimental group was significantly lower than that of the control group [mean difference (MD) =-5.10, 95% CI: -7.95 to -2.24; P=0.0005], the estradiol level of the experimental group was significantly higher than that of the control group (MD =10.74, 95% CI: 4.19 to 17.29; P=0.001), the testosterone level of the experimental group was significantly lower than that of the control group (MD =-1.17, 95% CI: -2.09 to -0.25; P=0.01), and the pregnancy rate of the experimental group was significantly higher than that of the control group (RR =1.36, 95% CI: 1.13 to 1.64; Z=3.183; P=0.001).

DISCUSSION

The therapeutic effect of Jinfeng pills combined with Western medicine in treating PCOS was better than that of Western medicine alone, and there was no increase in adverse reactions.