Ye Wenguo, Deng Gen, Yin Lin, Ye Jing
Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine.
Jiangxi University of Traditional Chinese Medicine, Nanchang, China.
Medicine (Baltimore). 2021 Mar 19;100(11):e24529. doi: 10.1097/MD.0000000000024529.
Polycystic ovary syndrome (PCOS) is one of the common diseases of reproductive endocrine metabolism in gynecology, and it is also a common and difficult disease affecting female reproductive endocrine health. PCOS characterized by insulin resistance and hyperandrogenemia, the clinical manifestations are polychaemia, acne, obesity, infertility, menstrual disorders and so on. Clinical treatment of patients with PCOS ovulatory dysfunction infertility is mainly treated with ovulation-promoting drugs, insulin sensitizer, hyperandrogenemia drugs and other drugs Healing. It is found that the sensitivity of patients to ovulation promotion is poor, and it is often necessary to increase the dosage of drugs to increase ovulation rate, thus increasing the risk of ovarian hyperstimulation syndrome, and the recurrence rate is higher after withdrawal. Moxibustion therapy has shown strong advantages in the treatment of PCOS, and the curative effect is accurate. Therefore, this paper will carry out a systematic evaluation and meta-analysis of the efficacy and safety of moxibustion therapy in the treatment of PCOS.
We will search 8 electronic databases, including PubMed, Embase, Web of Science, Cochrane Library, the China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), Wanfang Database (WF), and Chinese Biomedical Literature Database (CBM). We will search above electronic databases from the beginning to January 2021, without any language restriction. Ovulation rate and pregnancy rate will be accepted as the primary outcomes. The changes of Sex hormone levels, including Luteinizing hormone, follicle-stimulating hormone, serum estradiol, total testosterone will be used as secondary outcomes. RevMan 5.3 software will be used for statistical analysis. The result about the curative effect and safety of moxibustion therapy for PCOS will be presented as risk ratio for dichotomous data and mean differences with a 95% confidence interval for continuous data.
Only when we finish this meta-analysis can we get the result.
The results of this study will provide reliable evidence for the efficacy and safety of moxibustion therapy in the treatment of PCOS.
多囊卵巢综合征（PCOS）是妇科常见的生殖内分泌代谢疾病之一，也是影响女性生殖内分泌健康的常见疑难病症。PCOS以胰岛素抵抗和高雄激素血症为特征，临床表现为多毛、痤疮、肥胖、不孕、月经紊乱等。临床治疗PCOS排卵功能障碍性不孕主要采用促排卵药物、胰岛素增敏剂、高雄激素血症药物等进行治疗。发现患者对促排卵的敏感性较差，常需增加药物剂量以提高排卵率，从而增加卵巢过度刺激综合征的风险，且停药后复发率较高。艾灸疗法在PCOS的治疗中显示出较强优势，疗效确切。因此，本文将对艾灸疗法治疗PCOS的疗效和安全性进行系统评价和Meta分析。
我们将检索8个电子数据库，包括PubMed、Embase、Web of Science、Cochrane图书馆、中国知网（CNKI）、中国科技期刊数据库（VIP）、万方数据库（WF）和中国生物医学文献数据库（CBM）。我们将检索上述电子数据库至2021年1月，无任何语言限制。排卵率和妊娠率将作为主要结局。性激素水平的变化，包括促黄体生成素、促卵泡生成素、血清雌二醇、总睾酮，将作为次要结局。将使用RevMan 5.3软件进行统计分析。艾灸疗法治疗PCOS的疗效和安全性结果将以二分类数据的风险比和连续数据的95%置信区间的均值差异表示。
只有当我们完成这项Meta分析才能得到结果。
本研究结果将为艾灸疗法治疗PCOS的疗效和安全性提供可靠证据。
