Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Institute for Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia.
Neoplasma. 2022 Mar;69(2):264-273. doi: 10.4149/neo_2022_220127N121. Epub 2022 Feb 10.
Programmed cell death is a basic feature of chemotherapeutic (and also radiotherapeutic) intervention. Induction of cell death in tumor cells aims to kill preferentially the tumor cells, with minimal impact on the normal cells. Although apoptosis is the most obvious type of cell death induced by chemotherapeutics, several other types can also be activated, especially in conditions, where cells are resistant to apoptosis induction. Calcium signaling was shown to play an indisputable role in the activation of different types of cell death. Local increase of the calcium in time and precise place of this increase is secured by calcium transport systems. In this review, we summarized the involvement of some calcium transport systems in apoptosis, autophagy, necroptosis, ferroptosis, and mitophagy during cancer development and treatment.
程序性细胞死亡是化学治疗（以及放射治疗）干预的一个基本特征。诱导肿瘤细胞死亡的目的是优先杀死肿瘤细胞，而对正常细胞的影响最小。虽然凋亡是化疗诱导的最明显的细胞死亡类型，但也可以激活几种其他类型的细胞死亡，特别是在细胞对凋亡诱导有抗性的情况下。钙信号被证明在不同类型的细胞死亡的激活中起着不可争议的作用。通过钙转运系统来确保钙在时间和精确的位置上的局部增加。在这篇综述中，我们总结了一些钙转运系统在癌症发生和治疗过程中参与凋亡、自噬、坏死性凋亡、铁死亡和线粒体自噬的情况。
