艾滋病毒晚期患者中注射毒品人群的流行率：一项荟萃分析。

The prevalence of people who inject drugs among those with HIV late presentation: a meta-analysis.

机构信息

Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

出版信息

Subst Abuse Treat Prev Policy. 2022 Feb 10;17(1):11. doi: 10.1186/s13011-022-00439-5.

DOI:10.1186/s13011-022-00439-5

PMID:35144631

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8832672/

Abstract

BACKGROUND

One of the most important routes of HIV transmission is through injections of drugs, and this group, due to unawareness of their infection, causes the spread of HIV. The coexistence of other opportunistic infections and diseases with HIV among people who inject drugs (PWID) imposes healthcare costs and is associated with high morbidity/mortality rates. Early detection of HIV among PWID is essential to prevent and control the spread of the disease.

OBJECTIVES

This study aimed to determine the prevalence of PWID among those with late presentation (LP).

METHODS

Three electronic databases of PubMed, Scopus, and Web of science were searched using appropriate keywords. Besides the prevalence data reported for PWID among LP, the other outcomes of interest were LP defined as having CD4 count < 350 cells/μL or HIV or advanced disease defined with CD4 count < 200 cells/μL or HIV at the time of diagnosis.

RESULTS

Of the 160 studies found, only eight met the inclusion criteria. Among those presented late, 36.5% were PWID (95% CI = 24.88-48.17). Compared with men who have sex with men (MSM), HIV-infected PWID had a higher risk of LP [OR = 1.51; 95% CI = 0.96-2.06].

CONCLUSION

The results of this study show that HIV is diagnosed late in the majority of PWID when CD4 is less than 350 cells/μL. Targeted interventions/strategies are highly required to reduce LP among HIV-infected PWID.

摘要

背景

HIV 传播的最重要途径之一是通过注射毒品，而由于这些人群对自身感染状况缺乏认识，导致 HIV 进一步传播。在注射毒品者（PWID）中，HIV 与其他机会性感染和疾病同时存在，增加了医疗保健成本，并与高发病率/死亡率相关。早期发现 PWID 中的 HIV 对于预防和控制疾病的传播至关重要。

目的

本研究旨在确定晚期就诊（LP）人群中 PWID 的患病率。

方法

使用适当的关键词在 PubMed、Scopus 和 Web of science 这三个电子数据库中进行检索。除了报告的 LP 中 PWID 的流行率数据外，其他感兴趣的结果还包括 LP 定义为 CD4 计数<350 个细胞/μL 或 HIV，或在诊断时 CD4 计数<200 个细胞/μL 或 HIV 时定义为晚期疾病。