Wang Lihua, Zhang Shengkui, Yu Miao, Yuan Juxiang
Department of Epidemiology and Health Statistics. School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, China.
Hypertens Res. 2022 Apr;45(4):686-697. doi: 10.1038/s41440-021-00821-z. Epub 2022 Feb 10.
This study aimed to examine the association between rotating night shift work and carotid atherosclerosis in Chinese steelworkers. A total of 3582 subjects were included in this study. Different exposure metrics of night shifts, including current shift status, duration of night shifts (years), the cumulative number of night shifts (nights), cumulative length of night shifts (hours) and average frequency of night shifts (nights/month), were used to examine the relationship between night shift work and carotid atherosclerosis, including carotid plaque and carotid plaque scores. The prevalence of carotid plaque was 29.9% in the study population. Compared with day workers, significantly increased odds of carotid plaque were observed among shift workers in each quartile of the duration of night shifts after adjusting for potential confounders, especially in the third and fourth quartiles: odds ratio (OR) = 1.91, 95% confidence interval (CI): 1.46 to 2.49, in the third quartiles; OR = 1.69, 95% CI: 1.30 to 2.20, in the fourth quartiles. Positive associations of different exposure metrics of night shifts (continuous) with the odds of carotid plaque and the carotid plaque score were observed in the restricted cubic spline (RCS) models. No significant association was found in female workers between night shift work and carotid plaque. Rotating night shift work is associated with elevated odds of carotid atherosclerosis in male steelworkers.
本研究旨在探讨中国钢铁工人中轮值夜班工作与颈动脉粥样硬化之间的关联。本研究共纳入3582名受试者。采用不同的夜班暴露指标，包括当前班次状态、夜班时长（年）、夜班累积次数（晚）、夜班累积时长（小时）和夜班平均频率（晚/月），来研究夜班工作与颈动脉粥样硬化（包括颈动脉斑块和颈动脉斑块评分）之间的关系。研究人群中颈动脉斑块的患病率为29.9%。在调整潜在混杂因素后，与日班工人相比，各四分位数夜班时长的轮班工人中颈动脉斑块的发生几率显著增加，尤其是在第三和第四四分位数：第三四分位数中，比值比（OR）=1.91，95%置信区间（CI）：1.46至2.49；第四四分位数中，OR=1.69，95%CI：1.30至2.20。在受限立方样条（RCS）模型中观察到夜班不同暴露指标（连续变量）与颈动脉斑块发生几率和颈动脉斑块评分呈正相关。在女性工人中，未发现夜班工作与颈动脉斑块之间存在显著关联。轮值夜班工作与男性钢铁工人颈动脉粥样硬化的发生几率升高有关。
