Department of Physiology and Aging, University of Florida, Gainesville, Florida, USA; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, USA; Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida, USA.
Department of Physiology and Aging, University of Florida, Gainesville, Florida, USA; Division of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, USA; Center for Integrative Cardiovascular and Metabolic Disease, University of Florida, Gainesville, Florida, USA.
Can J Cardiol. 2023 Dec;39(12):1757-1771. doi: 10.1016/j.cjca.2023.06.416. Epub 2023 Jun 22.
Circadian rhythms are crucial for maintaining vascular function and disruption of these rhythms are associated with negative health outcomes including cardiovascular disease and hypertension. Circadian rhythms are regulated by the central clock within the suprachiasmatic nucleus of the hypothalamus and peripheral clocks located in nearly every cell type in the body, including cells within the heart and vasculature. In this review, we summarize the most recent preclinical and clinical research linking circadian disruption, with a focus on molecular circadian clock mechanisms, in atherosclerosis and hypertension. Furthermore, we provide insight into potential future chronotherapeutics for hypertension and vascular disease. A better understanding of the influence of daily rhythms in behaviour, such as sleep/wake cycles, feeding, and physical activity, as well as the endogenous circadian system on cardiovascular risk will help pave the way for targeted approaches in atherosclerosis and hypertension treatment/prevention.
昼夜节律对于维持血管功能至关重要，这些节律的紊乱与负面健康结果相关，包括心血管疾病和高血压。昼夜节律受下丘脑视交叉上核中的中央时钟和位于身体几乎每一种细胞类型中的外周时钟调节，包括心脏和血管中的细胞。在这篇综述中，我们总结了最近的临床前和临床研究，这些研究将昼夜节律紊乱与动脉粥样硬化和高血压中的分子昼夜节律机制联系起来。此外，我们还提供了对高血压和血管疾病潜在未来时间治疗的见解。更好地了解行为（如睡眠/觉醒周期、进食和体力活动）以及内源性昼夜节律系统对心血管风险的影响，将有助于为动脉粥样硬化和高血压治疗/预防的靶向方法铺平道路。
