Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
National Metabolic Management Center, Shanghai Tenth People's Hospital, Shanghai, China.
Front Endocrinol (Lausanne). 2022 Jan 25;12:782808. doi: 10.3389/fendo.2021.782808. eCollection 2021.
This study aims to investigate the correlation between serum uric acid levels and body fat distribution in patients with polycystic ovary syndrome (PCOS).
Between May 2017 and March 2021, a total of 199 patients with PCOS were recruited from the Department of Endocrinology and Metabolism at the Shanghai Tenth People's Hospital. Anthropometric characteristics, metabolic parameters, and reproductive hormones were measured. Hyperuricemia was defined as serum uric acid (SUA) greater than 420 μmol/l. Dual-energy X-ray absorptiometry (DEXA) was used to measure body fat distribution.
The prevalence of hyperuricemia in patients with PCOS was 28.64%. PCOS patients with hyperuricemia are more obese and have a higher waist-to-hip ratio (WHR) and worse lipid metabolism than those without hyperuricemia. According to SUA quartiles, patients in the highest quartile had higher total testosterone (TT), body fat accumulation, and lower sex hormone-binding globulin (SHBG) than patients in the lowest quartile. SUA was correlated with percentage of total body fat, arm fat mass, leg fat mass, trunk fat mass, android/gynoid (A/G) ratio, and visceral adipose tissue (VAT) mass. After controlling possible confounders, logistic regression analysis found that only excessive VAT mass could significantly increase the risk of hyperuricemia in patients with PCOS.
In patients with PCOS, a high level of VAT mass, but not other fat compartments, will exacerbate the risk of hyperuricemia. Attention should be paid to the role of excessive VAT in the occurrence and development of PCOS with hyperuricemia.
本研究旨在探讨多囊卵巢综合征（PCOS）患者血清尿酸水平与体脂分布的相关性。
2017 年 5 月至 2021 年 3 月，共招募 199 例来自上海第十人民医院内分泌代谢科的 PCOS 患者。测量人体测量特征、代谢参数和生殖激素。高尿酸血症定义为血清尿酸（SUA）大于 420 μmol/l。双能 X 射线吸收法（DEXA）用于测量体脂分布。
PCOS 患者高尿酸血症的患病率为 28.64%。与无高尿酸血症的患者相比，患有高尿酸血症的 PCOS 患者更肥胖，腰臀比（WHR）更高，血脂代谢更差。根据 SUA 四分位值，SUA 最高四分位数的患者总睾酮（TT）更高，体脂堆积更多，性激素结合球蛋白（SHBG）水平更低。SUA 与全身脂肪百分比、手臂脂肪量、腿部脂肪量、躯干脂肪量、安卓/女性（A/G）比值和内脏脂肪组织（VAT）质量相关。在控制可能的混杂因素后，逻辑回归分析发现，只有过多的 VAT 质量才能显著增加 PCOS 患者高尿酸血症的风险。
在 PCOS 患者中，VAT 质量的增加而不是其他脂肪区，会加重高尿酸血症的风险。应注意过多的 VAT 在伴有高尿酸血症的 PCOS 发生和发展中的作用。
