Purdy C W, Livingston C W, Frank G H, Cummins J M, Cole N A, Loan R W
J Am Vet Med Assoc. 1986 Mar 15;188(6):589-91.
A live Pasteurella haemolytica serotype 1 vaccine was used in an efficacy trial conducted on 100 lightweight feeder calves purchased from a Florida ranch. Forty-one calves were inoculated with the vaccine intradermally in the neck. Fifty-nine calves served as nonvaccinated controls. Fourteen days later, the calves were shipped to an order buyer in eastern Tennessee, where the calves were mixed with 60 local calves in a community sale barn for 72 hours. After 3 additional days, the calves were shipped to a research feedlot in Bushland, Tex. They remained in the feedlot for 56 days, and the test was concluded 76 days after vaccination. The P haemolytica vaccine had no significant effect on performance, morbidity, or mortality. There was no significant difference between the vaccinated and nonvaccinated calves in the number of times Pasteurella was isolated. The calves became seropositive to bovine viral diarrhea virus, respiratory syncytial virus, and infectious bovine rhinotracheitis (IBR) virus during the 76-day experiment. All calves initially were seropositive to parainfluenza-3 virus. A virulent outbreak of IBR occurred 30 days after the calves arrived at the feedlot. Before the onset of IBR, the isolation of P haemolytica serotype 1 from nasal turbinates was rare (2 of 500 nasal swabs). After the IBR outbreak, P haemolytica serotype 1 was isolated from 40 of 92 calves.
一种活的溶血巴斯德菌1型疫苗在一项对从佛罗里达牧场购买的100头轻量级育肥牛犊进行的效力试验中使用。41头犊牛在颈部进行皮内接种疫苗。59头犊牛作为未接种疫苗的对照。14天后，这些犊牛被运往田纳西州东部的一位订单买家那里，在那里这些犊牛与60头当地犊牛在一个社区销售棚中混合72小时。再过3天后，这些犊牛被运往得克萨斯州布什兰的一个研究饲养场。它们在饲养场里待了56天，试验在接种疫苗76天后结束。溶血巴斯德菌疫苗对生长性能、发病率或死亡率没有显著影响。接种疫苗和未接种疫苗的犊牛在分离出巴斯德菌的次数上没有显著差异。在76天的试验期间，犊牛对牛病毒性腹泻病毒、呼吸道合胞病毒和传染性牛鼻气管炎（IBR）病毒呈血清阳性。所有犊牛最初对副流感3型病毒呈血清阳性。犊牛到达饲养场30天后发生了一次IBR的烈性暴发。在IBR暴发之前，从鼻甲中分离出1型溶血巴斯德菌的情况很少见（500份鼻拭子中有2份）。在IBR暴发后，92头犊牛中有40头分离出了1型溶血巴斯德菌。
