Kadel W L, Chengappa M M, Herren C E
Am J Vet Res. 1985 Sep;46(9):1944-8.
A field-trial evaluation confirmed the efficacy of a pasteurella vaccine as a means of preventing bovine pneumonia. The vaccine was comprised of streptomycin-dependent Pasteurella multocida (type A:3) and Pasteurella haemolytica (type 1). Vaccinal efficacy was defined in terms of greater body weight gains, less severe clinical signs of pneumonia, and smaller death rates as compared with the same factors in nonvaccinated calves. During the 50-day trial, vaccinated calves gained weight faster than did nonvaccinated calves (P = 0.05). Economic advantage was not found for administering a booster dose of the vaccine (P = 0.25). Nonpreconditioned nonvaccinated calves made greater dollar profits than did preconditioned nonvaccinated calves (P = 0.16). A comparison of all preconditioned calves with all nonpreconditioned calves revealed that illness and death losses were less in the preconditioned calves (P = 0.07). An evaluation of the cost vs benefit factors revealed significant advantages for administering 1 dose of vaccine of $19.08 for a preconditioned calf (P = 0.006) and of $11.39 for a nonpreconditioned calf (P = 0.05). The data indicated that there was no economic advantage for preconditioning and that the greatest economic gain was made by the vaccinated nonpreconditioned calves.
一项田间试验评估证实了一种巴氏杆菌疫苗作为预防牛肺炎手段的有效性。该疫苗由依赖链霉素的多杀性巴氏杆菌（A:3型）和溶血巴氏杆菌（1型）组成。疫苗效力的定义是，与未接种疫苗的小牛相比，接种疫苗的小牛体重增加更多、肺炎临床症状更轻、死亡率更低。在为期50天的试验中，接种疫苗的小牛比未接种疫苗的小牛体重增加得更快（P = 0.05）。未发现接种疫苗加强剂量具有经济优势（P = 0.25）。未经预处理的未接种疫苗的小牛比经过预处理的未接种疫苗的小牛获得了更高的美元利润（P = 0.16）。将所有经过预处理的小牛与所有未经预处理的小牛进行比较发现，经过预处理的小牛的疾病和死亡损失更少（P = 0.07）。对成本与效益因素的评估表明，给一头经过预处理的小牛接种一剂19.08美元的疫苗具有显著优势（P = 0.006），给一头未经预处理的小牛接种一剂11.39美元的疫苗也具有显著优势（P = 0.05）。数据表明，预处理没有经济优势，接种疫苗的未经预处理的小牛获得了最大的经济收益。
