Almosa Fadel Ali M, Alnasser Ali Hassan A, Al-Tawfiq Jaffar A
Gastroenterology Unit, Department of Internal Medicine, Qatif Central Hospital, Ministry of Health, Qatif, Saudi Arabia.
Department of Laboratory, Dhahran Eye Specialist Hospital, Ministry of Health, Dhahran, Saudi Arabia.
Infez Med. 2021 Sep 10;29(3):450-455. doi: 10.53854/liim-2903-16. eCollection 2021.
Hepatitis C virus (HCV) is the leading cause of chronic liver disease. HCV genotypes and subtypes are important predictors of disease progression and antiviral treatment response. To our knowledge, there had been limited studies of HCV genotypes in Qatif, Saudi Arabia. This study aims to assess the distribution of HCV genotypes in Qatif Central Hospital, Qatif, Saudi Arabia. This is a retrospective study of adult patients with HCV infection between January 2015 and December 2020. Only patients with documented HCV genotyping were included. A total of 356 HCVinfected patients fulfilled the inclusion criteria and were included in further analysis. Of those patients, 179 (50.3%) were males, and most were Saudi (N=347, 97.5%). The median age was 60 years, and 191 (53.7%) were 50-69 years of age. Genotype 2 was present in 118 (33.1%) of the patients, followed by genotype 4 in 92 (25.8%), genotype 1B in 62 (17.4%), and genotype 1A in 37 (10.4%). The study showed that HCV genotype 2 is the predominant variant among chronic HCV patients in the study population. Monitoring the epidemiology of HCV genotypes may provide guidance in treatment decisions.
丙型肝炎病毒（HCV）是慢性肝病的主要病因。HCV基因型和亚型是疾病进展及抗病毒治疗反应的重要预测指标。据我们所知，沙特阿拉伯盖提夫地区关于HCV基因型的研究有限。本研究旨在评估沙特阿拉伯盖提夫中央医院HCV基因型的分布情况。这是一项对2015年1月至2020年12月期间成年HCV感染患者的回顾性研究。仅纳入有HCV基因分型记录的患者。共有356例HCV感染患者符合纳入标准并纳入进一步分析。在这些患者中，179例（50.3%）为男性，大多数为沙特人（N = 347，97.5%）。年龄中位数为60岁，191例（53.7%）年龄在50 - 69岁之间。2型基因型在118例（33.1%）患者中出现，其次是4型基因型92例（25.8%）、1B型基因型62例（17.4%）和1A型基因型37例（10.4%）。该研究表明，在研究人群的慢性HCV患者中，2型HCV基因型是主要变体。监测HCV基因型的流行病学情况可为治疗决策提供指导。
