Mauras N, Rogol A D, Clarke W L
J Clin Endocrinol Metab. 1986 May;62(5):975-9. doi: 10.1210/jcem-62-5-975.
Overnight serum insulin and plasma glucose concentrations were measured every 20 min from midnight to 0900 h in 13 nondiabetic subjects. Seven were normal men, and 6 had isolated GH deficiency. The pre-breakfast increase in serum insulin concentrations ("dawn phenomenon") did not occur in either group of individuals, and a progressive decline in serum insulin concentrations occurred particularly in the dawn hours (0600-0900 h). The GH secretory patterns were strikingly different in the two groups, with normal spontaneous GH peaks mostly between 0100-0200 h in the normal subjects vs. virtually flat GH secretion in the isolated GH deficiency group. The absence of the dawn phenomenon in these nondiabetic subjects regardless of their GH secretory pattern suggests that the dawn phenomenon, as described in insulin-dependent diabetic patients, is not an exaggeration of normal circadian rhythmicity in insulin sensitivity.
在13名非糖尿病受试者中，从午夜至09:00每20分钟测量一次过夜血清胰岛素和血浆葡萄糖浓度。其中7名是正常男性，6名患有孤立性生长激素缺乏症。两组个体均未出现早餐前血清胰岛素浓度升高（“黎明现象”），且血清胰岛素浓度尤其在黎明时段（06:00 - 09:00）逐渐下降。两组的生长激素分泌模式显著不同，正常受试者的正常自发性生长激素峰值大多出现在01:00 - 02:00之间，而孤立性生长激素缺乏组的生长激素分泌几乎呈平稳状态。这些非糖尿病受试者无论其生长激素分泌模式如何均未出现黎明现象，这表明胰岛素依赖型糖尿病患者中所描述的黎明现象并非胰岛素敏感性正常昼夜节律的夸大表现。
